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Literature DB >> 2554885

Studies on some specific Ap4A-degrading enzymes with the use of various methylene analogues of P1P4-bis-(5',5'''-adenosyl) tetraphosphate.

A Guranowski¹, E Starzyńska, G E Taylor, G M Blackburn.

Abstract

Six new methylenephosphonate analogues of P1P4-bis-(5',5'''-adenosyl) tetraphosphate, Ap4A, having P2-P3 carbon bridges CF2, CCl2 and CH2CH2 or P1-P2 and P3-P4 carbon bridges CF2, CCl2 and CH2CH2 in the tetraphosphate chain, were examined as substrates or inhibitors for two specific Ap4A-degrading enzymes: (asymmetrical) Ap4A hydrolase (EC 3.6.1.17) from yellow-lupin seeds and (symmetrical) Ap4A hydrolase (EC 3.6.1.41) from Escherichia coli. All analogues in which the central oxygen atom was replaced by a stable carbon bridge were hydrolysed by the asymmetrical hydrolase (CF2 greater than CCl2 greater than O greater than CHBr greater than CH2 greater than CH2CH2). As expected, these analogues were not hydrolysed by the symmetrical hydrolase, which was also unable to act on analogues having P1-P2 and P3-P4 carbon bridges.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2554885 PMCID： PMC1133253 DOI： 10.1042/bj2620241

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

28 in total

1. Diguanosinetetraphosphatase from rat liver: Acitivity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate.

Authors: C D Lobatón; C G Vallejo; A Sillero; M A Sillero
Journal: Eur J Biochem Date: 1975-01-15

2. Dinucleosidetriphosphatase from rat liver. Purification and properties.

Authors: M A Sillero; R Villalba; A Moreno; M Quintanilla; C D Lobatón; A Sillero
Journal: Eur J Biochem Date: 1977-06-15

3. Identification of point of specific enzymic cleavage of P1,P4-bis(5'-adenosyl) tetraphosphate by negative ion FAB mass spectrometry.

Authors: A G McLennan; M Prescott; R P Evershed
Journal: Biomed Environ Mass Spectrom Date: 1989-06

4. [Effect of diadenosine oligophosphates (Ap4A and Ap3A) and their phosphonate analogs on catalytic properties of phenylalanyl-tRNA synthetase from E. coli].

Authors: A P Biriukov; O D Zakharova; O I Lavrik
Journal: Bioorg Khim Date: 1987-09

5. Synthesis of (Rp,Rp)-P1,P4-Bis(5'-adenosyl)-1[17O,18O2],4[17O,18O2] tetraphosphate from (Sp,Sp)-P1,P4-Bis(5'-adenosyl)-1[thio-18O2], 4[thio-18O2]tetraphosphate with retention at phosphorus and the stereochemical course of hydrolysis by the unsymmetrical Ap4A phosphodiesterase from lupin seeds.

Authors: R M Dixon; G Lowe
Journal: J Biol Chem Date: 1989-02-05 Impact factor: 5.157

6. Recognition of beta beta'-substituted and alpha beta,alpha'beta'-disubstituted phosphonate analogues of bis(5'-adenosyl) tetraphosphate by the bis(5'-nucleosidyl)-tetraphosphate pyrophosphohydrolases from Artemia embryos and Escherichia coli.

Authors: A G McLennan; G E Taylor; M Prescott; G M Blackburn
Journal: Biochemistry Date: 1989-05-02 Impact factor: 3.162

7. Diadenosine 5',5'''-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells.

Authors: F Grummt
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

1. Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.

Authors: Andrzej Guranowski; Elzbieta Starzyńska; Alexander G McLennan; Janina Baraniak; Wojciech J Stec
Journal: Biochem J Date: 2003-07-15 Impact factor: 3.857

2. P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation.

Authors: D Lazewska; A Guranowski
Journal: Nucleic Acids Res Date: 1990-10-25 Impact factor: 16.971

2 in total