Mike van der Have1, Lianne K P M Brakenhoff2, Sanne J H van Erp2, Ad A Kaptein3, Max Leenders1, Margreet Scharloo3, Roeland A Veenendaal2, Désirée M F M van der Heijde4, Andrea E van der Meulen-de Jong2, Daan W Hommes5, Herma H Fidder6. 1. Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. 2. Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands. 3. Section of Medical Psychology, Leiden University Medical Centre, Leiden, The Netherlands. 4. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands. 5. Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands Centre for Inflammatory Bowel Diseases, UCLA Health System, Los Angeles, CA, USA. 6. Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
Abstract
BACKGROUND AND AIMS: Back and joint pain are the most common extraintestinal symptoms reported by patients with inflammatory bowel disease (IBD). We assessed the impact of back/joint pain, illness perceptions, and coping on quality of life (QOL) and work productivity in patients with IBD. METHODS: Our cohort included 155 IBD patients with and 100 without arthropathy. Arthropathy was defined as daily back pain for ≥3 months and/or peripheral joint pain and/or joint swelling over the last year. At baseline and at 12 months, patients completed questionnaires on the extent of back/joint pain, IBD disease activity, illness perceptions, coping, QOL, and work productivity. The impact of back/joint pain, illness perceptions and coping on QOL and work productivity was determined, using linear mixed models. RESULTS: In total, 204 IBD patients (72% Crohn's disease, 40% male, mean age 44 ± 14 years) completed questionnaires at both time points. At both time points, IBD patients with back/joint pain reported a significantly lower QOL and work productivity compared with IBD patients without back/joint pain. Predictors of low QOL were back/joint pain (β = -1.04, 95% confidence interval [CI] -1.40, -0.68), stronger beliefs about the illness consequences (β = -0.39, 95% CI -0.59, -0.18) and emotional impact of IBD (β = -0.47, 95% CI -0.66, -0.28), and the coping strategy 'decreasing activity' (β = -0.26, 95% CI -0.48, -0.03). Predictors of work productivity were back/joint pain (β = 0.22, 95% CI 0.07, 0.37) and illness consequences (β = 0.14, 95% CI 0.06, 0.22). CONCLUSION: Back/joint pain, illness perceptions, and coping are significant predictors of QOL and work productivity, after controlling for disease activity.
BACKGROUND AND AIMS: Back and joint pain are the most common extraintestinal symptoms reported by patients with inflammatory bowel disease (IBD). We assessed the impact of back/joint pain, illness perceptions, and coping on quality of life (QOL) and work productivity in patients with IBD. METHODS: Our cohort included 155 IBDpatients with and 100 without arthropathy. Arthropathy was defined as daily back pain for ≥3 months and/or peripheral joint pain and/or joint swelling over the last year. At baseline and at 12 months, patients completed questionnaires on the extent of back/joint pain, IBD disease activity, illness perceptions, coping, QOL, and work productivity. The impact of back/joint pain, illness perceptions and coping on QOL and work productivity was determined, using linear mixed models. RESULTS: In total, 204 IBDpatients (72% Crohn's disease, 40% male, mean age 44 ± 14 years) completed questionnaires at both time points. At both time points, IBDpatients with back/joint pain reported a significantly lower QOL and work productivity compared with IBDpatients without back/joint pain. Predictors of low QOL were back/joint pain (β = -1.04, 95% confidence interval [CI] -1.40, -0.68), stronger beliefs about the illness consequences (β = -0.39, 95% CI -0.59, -0.18) and emotional impact of IBD (β = -0.47, 95% CI -0.66, -0.28), and the coping strategy 'decreasing activity' (β = -0.26, 95% CI -0.48, -0.03). Predictors of work productivity were back/joint pain (β = 0.22, 95% CI 0.07, 0.37) and illness consequences (β = 0.14, 95% CI 0.06, 0.22). CONCLUSION:Back/joint pain, illness perceptions, and coping are significant predictors of QOL and work productivity, after controlling for disease activity.
Authors: M Severs; S J H van Erp; M E van der Valk; M J J Mangen; H H Fidder; M van der Have; A A van Bodegraven; D J de Jong; C J van der Woude; M J L Romberg-Camps; C H M Clemens; J M Jansen; P C van de Meeberg; N Mahmmod; C Y Ponsioen; C Bolwerk; J R Vermeijden; M J Pierik; P D Siersema; M Leenders; A E van der Meulen-de Jong; G Dijkstra; B Oldenburg Journal: J Crohns Colitis Date: 2015-12-30 Impact factor: 9.071
Authors: Jeannie S Huang; Laura Terrones; Alan N Simmons; Walter Kaye; Irina Strigo Journal: J Pediatr Gastroenterol Nutr Date: 2016-11 Impact factor: 2.839
Authors: S J H van Erp; L K M P Brakenhoff; M Vollmann; D van der Heijde; R A Veenendaal; H H Fidder; D W Hommes; A A Kaptein; Andrea E van der Meulen-de Jong; M Scharloo Journal: Int J Behav Med Date: 2017-04
Authors: Jonas Zeitz; Melike Ak; Séverine Müller-Mottet; Sylvie Scharl; Luc Biedermann; Nicolas Fournier; Pascal Frei; Valerie Pittet; Michael Scharl; Michael Fried; Gerhard Rogler; Stephan Vavricka Journal: PLoS One Date: 2016-06-22 Impact factor: 3.240