Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An epigenetic escape route.

Literature DB >> 25547197

An epigenetic escape route.

Abstract

Some of our fate is predetermined, by genetics and by the environment in the womb. Gestational environments are reflected in the DNA methylomes of newborns, in a manner that is often influenced by genotype. Therefore, DNA methylation serves as molecular mechanism linking the interplay of early life environments and genetics to later life health. As such, methylation marks are potential biomarkers of suboptimal developmental trajectories. Can DNA methylation also be used to construct an escape route from biological fate?

Keywords: DNA methylation; biomarker; developmental origins of health and disease (DoHAD); epigenetics; gene×environment; newborn

Mesh：

Substances：
Biomarkers

Year: 2015 PMID： 25547197 DOI： 10.1016/j.tig.2014.09.007

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

Keyword Cloud
Cited

6 in total

Review 1. Metabolism disrupting chemicals and metabolic disorders.

Authors: Jerrold J Heindel; Bruce Blumberg; Mathew Cave; Ronit Machtinger; Alberto Mantovani; Michelle A Mendez; Angel Nadal; Paola Palanza; Giancarlo Panzica; Robert Sargis; Laura N Vandenberg; Frederick Vom Saal
Journal: Reprod Toxicol Date: 2016-10-17 Impact factor: 3.143

2. HIF3A association with adiposity: the story begins before birth.

Authors: Hong Pan; Xinyi Lin; Yonghui Wu; Li Chen; Ai Ling Teh; Shu E Soh; Yung Seng Lee; Mya Thway Tint; Julia L MacIsaac; Alexander M Morin; Kok Hian Tan; Fabian Yap; Seang Mei Saw; Michael S Kobor; Michael J Meaney; Keith M Godfrey; Yap-Seng Chong; Peter D Gluckman; Neerja Karnani; Joanna D Holbrook
Journal: Epigenomics Date: 2015-05-26 Impact factor: 4.778

3. Gene, Environment and Methylation (GEM): a tool suite to efficiently navigate large scale epigenome wide association studies and integrate genotype and interaction between genotype and environment.

Authors: Hong Pan; Joanna D Holbrook; Neerja Karnani; Chee Keong Kwoh
Journal: BMC Bioinformatics Date: 2016-08-02 Impact factor: 3.169

An epigenetic escape route.

Review 1. Metabolism disrupting chemicals and metabolic disorders.

2. HIF3A association with adiposity: the story begins before birth.

3. Gene, Environment and Methylation (GEM): a tool suite to efficiently navigate large scale epigenome wide association studies and integrate genotype and interaction between genotype and environment.

Review 4. How to make DNA methylome wide association studies more powerful.

5. Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?

6. Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy.