Literature DB >> 25544784

On the definition of a confounder.

Tyler J VanderWeele1, Ilya Shpitser2.   

Abstract

The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The causal inference literature has not, however, produced a clear formal definition of a confounder, as it has given priority to the concept of confounding over that of a confounder. We consider a number of candidate definitions arising from various more informal statements made in the literature. We consider the properties satisfied by each candidate definition, principally focusing on (i) whether under the candidate definition control for all "confounders" suffices to control for "confounding" and (ii) whether each confounder in some context helps eliminate or reduce confounding bias. Several of the candidate definitions do not have these two properties. Only one candidate definition of those considered satisfies both properties. We propose that a "confounder" be defined as a pre-exposure covariate C for which there exists a set of other covariates X such that effect of the exposure on the outcome is unconfounded conditional on (X, C) but such that for no proper subset of (X, C) is the effect of the exposure on the outcome unconfounded given the subset. A variable that helps reduce bias but not eliminate bias we propose referring to as a "surrogate confounder."

Entities:  

Keywords:  Adjustment; causal diagrams; causal inference; confounder; counterfactuals; minimal sufficiency

Year:  2013        PMID: 25544784      PMCID: PMC4276366          DOI: 10.1214/12-aos1058

Source DB:  PubMed          Journal:  Ann Stat        ISSN: 0090-5364            Impact factor:   4.028


  12 in total

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5.  Stratification by a multivariate confounder score.

Authors:  O S Miettinen
Journal:  Am J Epidemiol       Date:  1976-12       Impact factor: 4.897

6.  Identifiability, exchangeability, and epidemiological confounding.

Authors:  S Greenland; J M Robins
Journal:  Int J Epidemiol       Date:  1986-09       Impact factor: 7.196

7.  Confounding and effect-modification.

Authors:  O Miettinen
Journal:  Am J Epidemiol       Date:  1974-11       Impact factor: 4.897

8.  The role of model selection in causal inference from nonexperimental data.

Authors:  J M Robins; S Greenland
Journal:  Am J Epidemiol       Date:  1986-03       Impact factor: 4.897

9.  Confounding: essence and detection.

Authors:  O S Miettinen; E F Cook
Journal:  Am J Epidemiol       Date:  1981-10       Impact factor: 4.897

10.  Identifiability, exchangeability and confounding revisited.

Authors:  Sander Greenland; James M Robins
Journal:  Epidemiol Perspect Innov       Date:  2009-09-04
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  53 in total

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Review 6.  Methods to control for unmeasured confounding in pharmacoepidemiology: an overview.

Authors:  Md Jamal Uddin; Rolf H H Groenwold; Mohammed Sanni Ali; Anthonius de Boer; Kit C B Roes; Muhammad A B Chowdhury; Olaf H Klungel
Journal:  Int J Clin Pharm       Date:  2016-04-18

7.  Diagnostics for Confounding of Time-varying and Other Joint Exposures.

Authors:  John W Jackson
Journal:  Epidemiology       Date:  2016-11       Impact factor: 4.822

8.  Theoretical Basis of the Test-Negative Study Design for Assessment of Influenza Vaccine Effectiveness.

Authors:  Sheena G Sullivan; Eric J Tchetgen Tchetgen; Benjamin J Cowling
Journal:  Am J Epidemiol       Date:  2016-09-01       Impact factor: 4.897

9.  Mediation Analysis for Health Disparities Research.

Authors:  Ashley I Naimi; Mireille E Schnitzer; Erica E M Moodie; Lisa M Bodnar
Journal:  Am J Epidemiol       Date:  2016-08-03       Impact factor: 4.897

10.  Ethnic variations in ulcerative colitis: Experience of an international hospital in Thailand.

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Journal:  World J Gastrointest Pharmacol Ther       Date:  2016-08-06
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