| Literature DB >> 25540941 |
Niki Chondrogianni1, Konstantinos Voutetakis2, Marianna Kapetanou2, Vasiliki Delitsikou2, Nikoletta Papaevgeniou2, Marianthi Sakellari3, Maria Lefaki2, Konstantina Filippopoulou2, Efstathios S Gonos4.
Abstract
Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in proteins leads to failure of proteostasis (or vice versa) due to increased levels of unfolded, misfolded or aggregated proteins and, in turn, to aging and/or age-related diseases. The major cellular proteolytic machineries, namely the proteasome and the lysosome, have been shown to dysfunction during aging and age-related diseases. Regarding the proteasome, it is well established that it can be activated either through genetic manipulation or through treatment with natural or chemical compounds that eventually result to extension of lifespan or deceleration of the progression of age-related diseases. This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity. Moreover, it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes.Entities:
Keywords: Age-related diseases; Aging; Longevity; Proteasome activation; Senescence; Ubiquitin–proteasome system
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Year: 2014 PMID： 25540941 DOI： 10.1016/j.arr.2014.12.003
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895