Literature DB >> 25540382

The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.

Claire M Metrick1, Pooja Chadha2, Ekaterina E Heldwein3.   

Abstract

UL21 is a conserved protein in the tegument of alphaherpesviruses and has multiple important albeit poorly understood functions in viral replication and pathogenesis. To provide a roadmap for exploration of the multiple roles of UL21, we determined the crystal structure of its conserved N-terminal domain from herpes simplex virus 1 to 2.0-Å resolution, which revealed a novel sail-like protein fold. Evolutionarily conserved surface patches highlight residues of potential importance for future targeting by mutagenesis.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25540382      PMCID： PMC4325721          DOI： 10.1128/JVI.03516-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

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Authors:  H Takakuwa; F Goshima; T Koshizuka; T Murata; T Daikoku; Y Nishiyama
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3.  Function of glycoprotein E of herpes simplex virus requires coordinated assembly of three tegument proteins on its cytoplasmic tail.

Authors:  Jun Han; Pooja Chadha; Jason L Starkey; John W Wills
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4.  The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.

Authors:  Sofia V Zaichick; Kevin P Bohannon; Ami Hughes; Patricia J Sollars; Gary E Pickard; Gregory A Smith
Journal:  Cell Host Microbe       Date:  2013-02-13       Impact factor: 21.023

5.  Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking.

Authors:  Jared D Pitts; Jenifer Klabis; Alexsia L Richards; Gregory A Smith; Ekaterina E Heldwein
Journal:  J Virol       Date:  2014-03-05       Impact factor: 5.103

6.  Herpes simplex virus gE/gI sorts nascent virions to epithelial cell junctions, promoting virus spread.

Authors:  D C Johnson; M Webb; T W Wisner; C Brunetti
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

7.  Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle.

Authors:  Ekaette F Mbong; Lucille Woodley; Elizabeth Frost; Joel D Baines; Carol Duffy
Journal:  J Virol       Date:  2012-04-11       Impact factor: 5.103

8.  The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virus.

Authors:  Julia Schipke; Anja Pohlmann; Randi Diestel; Anne Binz; Kathrin Rudolph; Claus-Henning Nagel; Rudolf Bauerfeind; Beate Sodeik
Journal:  J Virol       Date:  2012-01-18       Impact factor: 5.103

9.  Dali server: conservation mapping in 3D.

Authors:  Liisa Holm; Päivi Rosenström
Journal:  Nucleic Acids Res       Date:  2010-05-10       Impact factor: 16.971

10.  The herpes simplex virus 2 UL21 protein is essential for virus propagation.

Authors:  Valerie Le Sage; Masany Jung; Jake D Alter; Elizabeth G Wills; Susan M Johnston; Yasushi Kawaguchi; Joel D Baines; Bruce W Banfield
Journal:  J Virol       Date:  2013-03-13       Impact factor: 5.103
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  10 in total

1.  Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.

Authors:  Claire M Metrick; Ekaterina E Heldwein
Journal:  J Virol       Date:  2016-05-27       Impact factor: 5.103

2.  Domain Interaction Studies of Herpes Simplex Virus 1 Tegument Protein UL16 Reveal Its Interaction with Mitochondria.

Authors:  Pooja Chadha; Akua Sarfo; Dan Zhang; Thomas Abraham; Jillian Carmichael; Jun Han; John W Wills
Journal:  J Virol       Date:  2017-01-03       Impact factor: 5.103

3.  The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion.

Authors:  Kai Yan; Jie Liu; Xiang Guan; Yi-Xin Yin; Hui Peng; Huan-Chun Chen; Zheng-Fei Liu
Journal:  J Virol       Date:  2019-03-21       Impact factor: 5.103

4.  Molecular Evolution of Herpes Simplex Virus 2 Complete Genomes: Comparison between Primary and Recurrent Infections.

Authors:  Miguel A Minaya; Travis L Jensen; Johannes B Goll; Maria Korom; Sree H Datla; Robert B Belshe; Lynda A Morrison
Journal:  J Virol       Date:  2017-11-14       Impact factor: 5.103

5.  The UL21 Tegument Protein of Herpes Simplex Virus 1 Is Differentially Required for the Syncytial Phenotype.

Authors:  Akua Sarfo; Jason Starkey; Erica Mellinger; Dan Zhang; Pooja Chadha; Jillian Carmichael; John W Wills
Journal:  J Virol       Date:  2017-10-13       Impact factor: 5.103

6.  pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread.

Authors:  Tomasz H Benedyk; Julia Muenzner; Viv Connor; Yue Han; Katherine Brown; Kaveesha J Wijesinghe; Yunhui Zhuang; Susanna Colaco; Guido A Stoll; Owen S Tutt; Stanislava Svobodova; Dmitri I Svergun; Neil A Bryant; Janet E Deane; Andrew E Firth; Cy M Jeffries; Colin M Crump; Stephen C Graham
Journal:  PLoS Pathog       Date:  2021-08-16       Impact factor: 6.823

Review 7.  Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology.

Authors:  Yaru Ning; Yalin Huang; Mingshu Wang; Anchun Cheng; Qiao Yang; Ying Wu; Bin Tian; Xumin Ou; Juan Huang; Sai Mao; Di Sun; Xinxin Zhao; Shaqiu Zhang; Qun Gao; Shun Chen; Mafeng Liu; Dekang Zhu; Renyong Jia
Journal:  Front Microbiol       Date:  2022-08-04       Impact factor: 6.064

8.  Bovine herpesvirus 1 tegument protein UL21 plays critical roles in viral secondary envelopment and cell-to-cell spreading.

Authors:  Farzana Shahin; Sohail Raza; Kui Yang; Changmin Hu; Yingyu Chen; Huanchun Chen; Aizhen Guo
Journal:  Oncotarget       Date:  2017-10-10

9.  CRISPR/Cas9 Mutagenesis of UL21 in Multiple Strains of Herpes Simplex Virus Reveals Differential Requirements for pUL21 in Viral Replication.

Authors:  Renée L Finnen; Bruce W Banfield
Journal:  Viruses       Date:  2018-05-15       Impact factor: 5.048

10.  Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein.

Authors:  Claire M Metrick; Andrea L Koenigsberg; Ekaterina E Heldwein
Journal:  mBio       Date:  2020-05-05       Impact factor: 7.867
  10 in total

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