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Literature DB >> 22496211

Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle.

Ekaette F Mbong¹, Lucille Woodley, Elizabeth Frost, Joel D Baines, Carol Duffy.

Abstract

The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.

Entities: Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22496211 PMCID： PMC3393592 DOI： 10.1128/JVI.00411-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells.

Authors: H Takakuwa; F Goshima; T Koshizuka; T Murata; T Daikoku; Y Nishiyama
Journal: Genes Cells Date: 2001-11 Impact factor: 1.891

2. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing.

Authors: R M Sandri-Goldin; G E Mendoza
Journal: Genes Dev Date: 1992-05 Impact factor: 11.361

3. Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes.

Authors: P E Pellett; J L McKnight; F J Jenkins; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

4. En passant mutagenesis: a two step markerless red recombination system.

Authors: B Karsten Tischer; Gregory A Smith; Nikolaus Osterrieder
Journal: Methods Mol Biol Date: 2010

5. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription.

Authors: M E Campbell; J W Palfreyman; C M Preston
Journal: J Mol Biol Date: 1984-11-25 Impact factor: 5.469

6. Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.

Authors: G S Read; B M Karr; K Knight
Journal: J Virol Date: 1993-12 Impact factor: 5.103

7. Structural analysis of the capsid polypeptides of herpes simplex virus types 1 and 2.

Authors: G H Cohen; M Ponce de Leon; H Diggelmann; W C Lawrence; S K Vernon; R J Eisenberg
Journal: J Virol Date: 1980-05 Impact factor: 5.103

8. Herpes simplex virus type 1 ICP27 is an essential regulatory protein.

Authors: W R Sacks; C C Greene; D P Aschman; P A Schaffer
Journal: J Virol Date: 1985-09 Impact factor: 5.103

9. A subpopulation of tegument protein vhs localizes to detergent-insoluble lipid rafts in herpes simplex virus-infected cells.

Authors: Grace E Lee; Geoffrey A Church; Duncan W Wilson
Journal: J Virol Date: 2003-02 Impact factor: 5.103

10. Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo.

Authors: Michiko Tanaka; Hiroyuki Kagawa; Yuji Yamanashi; Tetsutaro Sata; Yasushi Kawaguchi
Journal: J Virol Date: 2003-01 Impact factor: 5.103

15 in total

1. Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.

Authors: Claire M Metrick; Ekaterina E Heldwein
Journal: J Virol Date: 2016-05-27 Impact factor: 5.103

2. The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.

Authors: Claire M Metrick; Pooja Chadha; Ekaterina E Heldwein
Journal: J Virol Date: 2014-12-24 Impact factor: 5.103

3. The Product of the Herpes Simplex Virus 2 UL16 Gene Is Critical for the Egress of Capsids from the Nuclei of Infected Cells.

Authors: Jie Gao; Thomas J M Hay; Bruce W Banfield
Journal: J Virol Date: 2017-04-28 Impact factor: 5.103

4. Domain Interaction Studies of Herpes Simplex Virus 1 Tegument Protein UL16 Reveal Its Interaction with Mitochondria.

Authors: Pooja Chadha; Akua Sarfo; Dan Zhang; Thomas Abraham; Jillian Carmichael; Jun Han; John W Wills
Journal: J Virol Date: 2017-01-03 Impact factor: 5.103

5. Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods.

Authors: Lauren M Oldfield; Peter Grzesik; Alexander A Voorhies; Nina Alperovich; Derek MacMath; Claudia D Najera; Diya Sabrina Chandra; Sanjana Prasad; Vladimir N Noskov; Michael G Montague; Robert M Friedman; Prashant J Desai; Sanjay Vashee
Journal: Proc Natl Acad Sci U S A Date: 2017-09-19 Impact factor: 11.205

Review 10. Nuclear Egress.

Authors: Elizabeth B Draganova; Michael K Thorsen; Ekaterina E Heldwein
Journal: Curr Issues Mol Biol Date: 2020-08-07 Impact factor: 2.081