Alberto R Ramos1, Wassim Tarraf1, Tatjana Rundek1, Susan Redline1, William K Wohlgemuth1, Jose S Loredo1, Ralph L Sacco1, David J Lee1, Raanan Arens1, Patricia Lazalde1, James P Choca1, Thomas Mosley1, Hector M González2. 1. From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing. 2. From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing. hmgonzalez@epi.msu.edu.
Abstract
OBJECTIVE: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States. METHODS: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores. RESULTS: The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β = -0.022) and -recall (β = -0.010), WF (β = -0.023), and DSS (β = -0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = -0.027, p < 0.10), SVELT-sum (β = -0.37), SVELT-recall (β = -0.010), and DSS (β = -0.061) at p < 0.01. CONCLUSION: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.
OBJECTIVE: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States. METHODS: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores. RESULTS: The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β = -0.022) and -recall (β = -0.010), WF (β = -0.023), and DSS (β = -0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = -0.027, p < 0.10), SVELT-sum (β = -0.37), SVELT-recall (β = -0.010), and DSS (β = -0.061) at p < 0.01. CONCLUSION: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.
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Authors: Alberto R Ramos; Wassim Tarraf; Benson Wu; Susan Redline; Jianwen Cai; Martha L Daviglus; Linda Gallo; Yasmin Mossavar-Rahmani; Krista M Perreira; Phyllis Zee; Donglin Zeng; Hector M Gonzalez Journal: Alzheimers Dement Date: 2020-01-06 Impact factor: 21.566
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Authors: Alberto R Ramos; Hannah Gardener; Tatjana Rundek; Mitchell S V Elkind; Bernadette Boden-Albala; Chuanhui Dong; Ying Kuen Cheung; Yaakov Stern; Ralph L Sacco; Clinton B Wright Journal: Neurology Date: 2016-09-02 Impact factor: 9.910