Dilip K Pandey1, Shvetank Bhatt2, Ankur Jindal2, Baldev Gautam2. 1. Department of Pharmacology, Novel Drug Discovery and Development, Lupin Ltd, Research Park, Nanded Village, Pune, Maharashtra, India. 2. Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
Abstract
OBJECTIVES: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant drugs. The addition of low dose of 5-hydroxytryptamine type 2A enhances the therapeutic effect of SSRIs. The purpose of the present studies was to test the effects of combined treatment of a low dose of ketanserin (KET) and escitalopram (ESC) on behavioral anomalies occurring after olfactory bulbectomy (OBX). MATERIALS AND METHODS: Chronic Depression was induced by OBX as shown in behavioral tests such as Open field, social interaction, and hyperemotionality tests. Acute and chronic treatment effect of KET, ESC, and combination was administered to the OBX rats. RESULTS: Chronic (14 days) treatment with KET (1 mg/kg) or ESC (10 mg/kg) alleviated the behavioral anomalies of olfactory bulbectomized rats in modified open field exploration, social interaction, hyperemotionality. When KET treatment was combined with ESC, a short duration regimen (7 days) was sufficient to reverse the bulbectomy-induced anomalies. CONCLUSION: The combination therapy as a likely strategy to achieve an early-onset of antidepressant action.
OBJECTIVES: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant drugs. The addition of low dose of 5-hydroxytryptamine type 2A enhances the therapeutic effect of SSRIs. The purpose of the present studies was to test the effects of combined treatment of a low dose of ketanserin (KET) and escitalopram (ESC) on behavioral anomalies occurring after olfactory bulbectomy (OBX). MATERIALS AND METHODS:Chronic Depression was induced by OBX as shown in behavioral tests such as Open field, social interaction, and hyperemotionality tests. Acute and chronic treatment effect of KET, ESC, and combination was administered to the OBX rats. RESULTS: Chronic (14 days) treatment with KET (1 mg/kg) or ESC (10 mg/kg) alleviated the behavioral anomalies of olfactory bulbectomized rats in modified open field exploration, social interaction, hyperemotionality. When KET treatment was combined with ESC, a short duration regimen (7 days) was sufficient to reverse the bulbectomy-induced anomalies. CONCLUSION: The combination therapy as a likely strategy to achieve an early-onset of antidepressant action.
Authors: Rodrigo Machado-Vieira; Giacomo Salvadore; David A Luckenbaugh; Husseini K Manji; Carlos A Zarate Journal: J Clin Psychiatry Date: 2008-06 Impact factor: 4.384
Authors: E V Gurevich; I A Aleksandrova; N A Otmakhova; Y A Katkov; I V Nesterova; N V Bobkova Journal: Pharmacol Biochem Behav Date: 1993-05 Impact factor: 3.533
Authors: Tatiana Ilchibaeva; Anton Tsybko; Andre Zeug; Franziska E Müller; Daria Guseva; Stephan Bischoff; Evgeni Ponimaskin; Vladimir Naumenko Journal: Cells Date: 2022-08-02 Impact factor: 7.666