Literature DB >> 1525654

Olfactory bulbectomy as a model for agitated hyposerotonergic depression.

A R Lumia1, M H Teicher, F Salchli, E Ayers, B Possidente.   

Abstract

Ablation of olfactory bulbs in rats reduced male sexual behavior, and altered the distribution of wheel-running activity between the light and dark phases of a 12:12 LD photoperiod. These effects were partially reversed by the tricyclic antidepressant amitriptyline. Olfactory bulbectomy also altered serotonin metabolism (5-HIAA/5-HT ratio) in the frontal cortex, nucleus accumbens, hippocampus and corpus striatum. These observations support the hypothesis that olfactory bulbectomy in rodents serves as a model of agitated hyposerotonergic depression.

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Year:  1992        PMID： 1525654     DOI： 10.1016/0006-8993(92)90995-l

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  29 in total

1.  Olfactory bulb neurons express functional, entrainable circadian rhythms.

Authors:  Daniel Granados-Fuentes; Meera T Saxena; Laura M Prolo; Sara J Aton; Erik D Herzog
Journal:  Eur J Neurosci       Date:  2004-02       Impact factor: 3.386

2.  Evaluation of reward processes in an animal model of depression.

Authors:  David A Slattery; Athina Markou; John F Cryan
Journal:  Psychopharmacology (Berl)       Date:  2006-12-20       Impact factor: 4.530

3.  Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study.

Authors:  Shu Hasegawa; Arata Watanabe; Khanh Q Nguyen; Guy Debonnel; Mirko Diksic
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

4.  A single episode of maternal deprivation impairs the motivation for cocaine in adolescent mice.

Authors:  Mariangela Martini; Olga Valverde
Journal:  Psychopharmacology (Berl)       Date:  2011-06-25       Impact factor: 4.530

Review 5.  Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action.

Authors:  Veska Uzunova; Luther Sampson; Doncho P Uzunov
Journal:  Psychopharmacology (Berl)       Date:  2005-10-26       Impact factor: 4.530

6.  Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system.

Authors:  Kohei Takahashi; Osamu Nakagawasai; Wataru Nemoto; Takeharu Nakajima; Yuichiro Arai; Tadashi Hisamitsu; Koichi Tan-No
Journal:  Psychopharmacology (Berl)       Date:  2016-02-09       Impact factor: 4.530

7.  Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats.

Authors:  Khanh Q Nguyen; Yoshihiro Tohyama; Arata Watanabe; Shu Hasegawa; Ivan Skelin; Mirko Diksic
Journal:  Neurochem Int       Date:  2008-11-27       Impact factor: 3.921

8.  SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model.

Authors:  M E Breuer; M M van Gaalen; W Wernet; S E F Claessens; R S Oosting; B Behl; S M Korte; H Schoemaker; G Gross; B Olivier; L Groenink
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-07-31       Impact factor: 3.000

9.  Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression.

Authors:  Thomas Romeas; Marie-Claude Morissette; Ouissame Mnie-Filali; Graciela Piñeyro; Sandra M Boye
Journal:  Psychopharmacology (Berl)       Date:  2009-04-29       Impact factor: 4.530

10.  Effect of combination of ketanserin and escitalopram on behavioral anomalies after olfactory bulbectomy: prediction of quick onset of antidepressant action.

Authors:  Dilip K Pandey; Shvetank Bhatt; Ankur Jindal; Baldev Gautam
Journal:  Indian J Pharmacol       Date:  2014 Nov-Dec       Impact factor: 1.200
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