Literature DB >> 25538274

Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology.

Ciaran Skerry1, Karen Scanlon1, Hugh Rosen2, Nicholas H Carbonetti1.   

Abstract

Recent pertussis resurgence represents a major public health concern. Currently, there are no effective treatments for critical pertussis in infants. Recent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the treatment of infectious diseases. We used the murine Bordetella pertussis model to test the hypothesis that treatment with S1PR agonist AAL-R reduces pulmonary inflammation during infection. AAL-R treatment resulted in reduced expression of inflammatory cytokines and chemokines and attenuated lung pathology in infected mice. These results demonstrate a role for sphingosine-1-phosphate (S1P) signaling in B. pertussis-mediated pathology and highlight the possibility of host-targeted therapy for pertussis.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  AAL-R; bordetella; host-directed; pertussis; sphingosine; sphingosine-1-phosphate

Mesh：

Substances：

Year:  2014        PMID： 25538274      PMCID： PMC4836722          DOI： 10.1093/infdis/jiu823

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

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3.  Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.

Authors:  Karen M Scanlon; Yael Gau; Jingsong Zhu; Ciaran Skerry; Susan M Wall; Manoocher Soleimani; Nicholas H Carbonetti
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Review 4.  The virulence factors of Bordetella pertussis: talented modulators of host immune response.

Authors:  Giorgio Fedele; Manuela Bianco; Clara Maria Ausiello
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2013-08-18       Impact factor: 4.291

5.  Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.

Authors:  Anthony S Don; Carolina Martinez-Lamenca; William R Webb; Richard L Proia; Ed Roberts; Hugh Rosen
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6.  Reduced risk of pertussis among persons ever vaccinated with whole cell pertussis vaccine compared to recipients of acellular pertussis vaccines in a large US cohort.

Authors:  Maxwell A Witt; Larry Arias; Paul H Katz; Elizabeth T Truong; David J Witt
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7.  The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.

Authors:  T Katada; M Tamura; M Ui
Journal:  Arch Biochem Biophys       Date:  1983-07-01       Impact factor: 4.013

8.  Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.

Authors:  Mohammad Sawal; Marta Cohen; Jose E Irazuzta; Ramani Kumar; Christine Kirton; Marie-Anne Brundler; Clair Anne Evans; John Andrew Wilson; Parakkal Raffeeq; Amer Azaz; Alexandre T Rotta; Ajay Vora; Amit Vohra; Patricia Abboud; L David Mirkin; Mehrengise Cooper; Megan K Dishop; Jeanine M Graf; Andy Petros; Hilary Klonin
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9.  Critical pertussis illness in children: a multicenter prospective cohort study.

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1.  Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to Bordetella pertussis and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation.

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Review 2.  Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.

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Review 4.  Novel therapies for the treatment of pertussis disease.

Authors:  Karen M Scanlon; Ciaran Skerry; Nicholas H Carbonetti
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5.  Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism.

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Journal:  J Infect Dis       Date:  2017-01-15       Impact factor: 5.226

Review 6.  Cracking the Challenge of Antimicrobial Drug Resistance with CRISPR/Cas9, Nanotechnology and Other Strategies in ESKAPE Pathogens.

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7.  Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages.

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Review 8.  Association of Pertussis Toxin with Severe Pertussis Disease.

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9.  Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease.

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10.  Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology.

Authors:  Danisha Gallop; Karen M Scanlon; Jeremy Ardanuy; Alexander B Sigalov; Nicholas H Carbonetti; Ciaran Skerry
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