Julienne E Bower1, Alexandra D Crosswell, Annette L Stanton, Catherine M Crespi, Diana Winston, Jesusa Arevalo, Jeffrey Ma, Steve W Cole, Patricia A Ganz. 1. Department of Psychology, University of California-Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, California; Cousins Center for Psychoneuroimmunology, University of California-Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, California.
Abstract
BACKGROUND:Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group. METHODS: This randomized trial provided the first evaluation of a brief, mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention group (n = 39) or to a wait-list control group (n = 32). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3-month follow-up assessment. RESULTS: In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in proinflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (P < .05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3-month follow-up assessment, although reductions in cancer-related distress were observed at that assessment. CONCLUSIONS: A brief, mindfulness-based intervention demonstrated preliminary short-term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors.
RCT Entities:
BACKGROUND: Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group. METHODS: This randomized trial provided the first evaluation of a brief, mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention group (n = 39) or to a wait-list control group (n = 32). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3-month follow-up assessment. RESULTS: In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in proinflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (P < .05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3-month follow-up assessment, although reductions in cancer-related distress were observed at that assessment. CONCLUSIONS: A brief, mindfulness-based intervention demonstrated preliminary short-term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors.
Authors: Emily E Ventura; Patricia A Ganz; Julienne E Bower; Liana Abascal; Laura Petersen; Annette L Stanton; Catherine M Crespi Journal: Breast Cancer Res Treat Date: 2013-11-01 Impact factor: 4.872
Authors: Andrew H Miller; Sonia Ancoli-Israel; Julienne E Bower; Lucile Capuron; Michael R Irwin Journal: J Clin Oncol Date: 2008-02-20 Impact factor: 44.544
Authors: Linda E Carlson; Richard Doll; Joanne Stephen; Peter Faris; Rie Tamagawa; Elaine Drysdale; Michael Speca Journal: J Clin Oncol Date: 2013-08-05 Impact factor: 44.544
Authors: Susan M Allen; Ann C Shah; Arthur M Nezu; Christine Maguth Nezu; Desirée Ciambrone; Joseph Hogan; Vincent Mor Journal: Cancer Date: 2002-06-15 Impact factor: 6.860
Authors: Julienne E Bower; Gail Greendale; Alexandra D Crosswell; Deborah Garet; Beth Sternlieb; Patricia A Ganz; Michael R Irwin; Richard Olmstead; Jesusa Arevalo; Steve W Cole Journal: Psychoneuroendocrinology Date: 2014-01-30 Impact factor: 4.905
Authors: Leorey N Saligan; Karin Olson; Kristin Filler; David Larkin; Fiona Cramp; Sriram Yennurajalingam; Yennu Sriram; Carmen P Escalante; Auro del Giglio; Kord M Kober; Jayesh Kamath; Oxana Palesh; Karen Mustian Journal: Support Care Cancer Date: 2015-05-15 Impact factor: 3.603
Authors: Joep van Agteren; Matthew Iasiello; Laura Lo; Jonathan Bartholomaeus; Zoe Kopsaftis; Marissa Carey; Michael Kyrios Journal: Nat Hum Behav Date: 2021-04-19
Authors: Karen H K Yeary; Kassandra I Alcaraz; Kimlin Tam Ashing; Chungyi Chiu; Shannon M Christy; Katarina Friberg Felsted; Qian Lu; Crystal Y Lumpkins; Kevin S Masters; Robert L Newton; Crystal L Park; Megan J Shen; Valerie J Silfee; Betina Yanez; Jean Yi Journal: Transl Behav Med Date: 2020-02-03 Impact factor: 3.046
Authors: Neha G Goyal; Beverly J Levine; Kimberly J Van Zee; Elizabeth Naftalis; Nancy E Avis Journal: Breast Cancer Res Treat Date: 2018-01-24 Impact factor: 4.872