Literature DB >> 2553354

Identification and regulation of the eukaryotic hyaluronate synthase.

P Prehm1.   

Abstract

Hyaluronate synthesis is required for fibroblast detachment in mitosis and migration. It is regulated by the activity of the synthase which is localized at the inner side of plasma membranes. The synthase was identified as a 50 kDa protein by immunological cross-reaction with the streptococcal enzyme and by affinity labelling. Transformation of fibroblasts by Rous sarcoma virus activated the synthase by enhanced transcription and phosphorylation. The synthase was a natural target of pp60v-src kinase.

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Year:  1989        PMID： 2553354     DOI： 10.1002/9780470513774.ch3

Source DB:  PubMed          Journal:  Ciba Found Symp        ISSN： 0300-5208


  15 in total

1.  Shedding of hyaluronate synthase from streptococci.

Authors:  A Mausolf; J Jungmann; H Robenek; P Prehm
Journal:  Biochem J       Date:  1990-04-01       Impact factor: 3.857

2.  Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation.

Authors:  Herbert H Lipowsky
Journal:  Drug Discov Today Dis Models       Date:  2011

3.  Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.

Authors:  P Heldin; T Asplund; D Ytterberg; S Thelin; T C Laurent
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

4.  Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes.

Authors:  Lujia Gao; Herbert H Lipowsky
Journal:  Microvasc Res       Date:  2010-06-21       Impact factor: 3.514

5.  Antibodies against proteins of streptococcal hyaluronate synthase bind to human fibroblasts and are present in patients with rheumatic fever.

Authors:  S Prehm; C Herrington; V Nickel; W Völker; N I Briko; E I Blinnikova; A Schmiedel; P Prehm
Journal:  J Anat       Date:  1995-10       Impact factor: 2.610

Review 6.  Hyaluronan: a simple polysaccharide with diverse biological functions.

Authors:  Kevin T Dicker; Lisa A Gurski; Swati Pradhan-Bhatt; Robert L Witt; Mary C Farach-Carson; Xinqiao Jia
Journal:  Acta Biomater       Date:  2013-12-18       Impact factor: 8.947

7.  The hyaluronate synthase from a eukaryotic cell line.

Authors:  L Klewes; E A Turley; P Prehm
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

8.  Regulation of proteoglycan and hyaluronan synthesis by elevated level of intracellular cyclic adenosine monophosphate in peritubular cells from immature rat testis.

Authors:  B Thiébot; M Langris; P J Bonnamy; J Bocquet
Journal:  Mol Cell Biochem       Date:  1998-10       Impact factor: 3.396

9.  CD44 variant isoforms are preferentially expressed in basal epithelial of non-malignant human fetal and adult tissues.

Authors:  H J Terpe; H Stark; P Prehm; U Günthert
Journal:  Histochemistry       Date:  1994-02

10.  Localisation of hyaluronate (HA) in primary tumors and nude mouse xenografts of human pancreatic carcinomas using a biotinylated HA-binding protein.

Authors:  H Fries; H P Elsässer; V Mahlbacher; K Neumann; H F Kern
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064
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