Sean P Heffron1, Caron B Rockman2, Eugenia Gianos3, Yu Guo4, Jeffrey S Berger5. 1. Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: sean.heffron@nyumc.org. 2. Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: caron.rockman@nyumc.org. 3. Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: eugenia.gianos@nyumc.org. 4. Department of Population Health, Division of Biostatistics, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: yu.guo@nyumc.org. 5. Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA; Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center, New York University School of Medicine, 550 First Avenue, New York, NY, USA. Electronic address: jeffrey.berger@nyumc.org.
Abstract
UNLABELLED: Nut consumption has been associated with lower risk of coronary heart disease and all-cause mortality. The association between nut intake and peripheral arterial disease (PAD) is uncertain. OBJECTIVE: We sought to investigate the association between nut consumption and presence of prevalent PAD in a large cross-sectional sample. METHODS: Self-referred participants at >20,000 US sites who completed a medical and lifestyle questionnaire were evaluated by screening ankle brachial indices for PAD. Multivariable logistic regression analysis was used to estimate odds of PAD in different nut consumption categories. RESULTS: Among 3,312,403 individuals, mean age was 63.6 ± 10.6 years and 62.8% were female. There were 219,527 cases of PAD. After multivariable adjustment there was an inverse association of nut intake with PAD. Compared to subjects with consumption of nuts<once/month, daily nut consumption was associated with a 21% (95% CI 20%-23%) lower odds of having PAD. CONCLUSION: These observations suggest the need for more rigorous testing evaluating the role of nuts in PAD prevention.
UNLABELLED: Nut consumption has been associated with lower risk of coronary heart disease and all-cause mortality. The association between nut intake and peripheral arterial disease (PAD) is uncertain. OBJECTIVE: We sought to investigate the association between nut consumption and presence of prevalent PAD in a large cross-sectional sample. METHODS: Self-referred participants at >20,000 US sites who completed a medical and lifestyle questionnaire were evaluated by screening ankle brachial indices for PAD. Multivariable logistic regression analysis was used to estimate odds of PAD in different nut consumption categories. RESULTS: Among 3,312,403 individuals, mean age was 63.6 ± 10.6 years and 62.8% were female. There were 219,527 cases of PAD. After multivariable adjustment there was an inverse association of nut intake with PAD. Compared to subjects with consumption of nuts<once/month, daily nut consumption was associated with a 21% (95% CI 20%-23%) lower odds of having PAD. CONCLUSION: These observations suggest the need for more rigorous testing evaluating the role of nuts in PAD prevention.
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