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Literature DB >> 2553225

Evidence for in vivo upregulation of 1,25(OH)2 vitamin D3 receptor in human monocytes.

J Merke¹, M Nawrot, U Hügel, A Szabo, E Ritz.

Abstract

Mammalian cells increase net expression of 1,25(OH) 2D3 receptors after exposure to physiological concentrations of 1,25(OH) 2D3 in vitro. We examined specific binding of 1,25(OH) 2D3 by human monocytes before and after daily administration of 1.5-2 micrograms 1,25(OH) 2D3 p.o. for 3 days in 5 healthy normal D-replete probands. Median specific binding (Nmax) at baseline was 793 molecules/cell and 2052 or 2828 at 24h and 72h of 1,25(OH) 2D3 treatment respectively. The results suggest (a) upregulation of 1,25(OH) 2D3 receptors occurs in man and (b) monocyte preparations can be used to assess receptor regulation in vivo.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2553225 DOI： 10.1007/BF02556046

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

8 in total

1. Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide.

Authors: M A Pellegrino; S Ferrone; M P Dierich; R A Reisfeld
Journal: Clin Immunol Immunopathol Date: 1975-01

2. No 1,25-dihydroxyvitamin D3 receptors on osteoclasts of calcium-deficient chicken despite demonstrable receptors on circulating monocytes.

Authors: J Merke; G Klaus; U Hügel; R Waldherr; E Ritz
Journal: J Clin Invest Date: 1986-01 Impact factor: 14.808

3. Reduced binding of [3H]1,25-dihydroxyvitamin D3 in the parathyroid glands of patients with renal failure.

Authors: A B Korkor
Journal: N Engl J Med Date: 1987-06-18 Impact factor: 91.245

4. Measurement of 1,25-dihydroxyvitamin D3 receptor turnover by dense amino acid labeling: changes during receptor up-regulation by vitamin D metabolites.

Authors: E M Costa; D Feldman
Journal: Endocrinology Date: 1987-03 Impact factor: 4.736

1 in total

1. Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor.

Authors: X P Yu; F G Hustmyer; W T Garvey; S C Manolagas
Journal: Proc Natl Acad Sci U S A Date: 1991-10-01 Impact factor: 11.205

1 in total

Evidence for in vivo upregulation of 1,25(OH)2 vitamin D3 receptor in human monocytes.

1. Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide.

2. No 1,25-dihydroxyvitamin D3 receptors on osteoclasts of calcium-deficient chicken despite demonstrable receptors on circulating monocytes.

3. Reduced binding of [3H]1,25-dihydroxyvitamin D3 in the parathyroid glands of patients with renal failure.

4. Measurement of 1,25-dihydroxyvitamin D3 receptor turnover by dense amino acid labeling: changes during receptor up-regulation by vitamin D metabolites.

5. Homologous up-regulation of the 1,25 (OH)2 vitamin D3 receptor in rats.

6. Demonstration and characterization of 1,25-dihydroxyvitamin D3 receptors in human mononuclear blood cells.

7. Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat.

8. Antigens on human monocytes identified by monoclonal antibodies.

1. Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor.