Literature DB >> 2553093

No significant correlation between specific antibodies to mouse mammary tumour virus and human cancer.

A Kovarík1, K Hlubinová, J Prachar, D Simkovic, J Knotek.   

Abstract

To study the possible involvement of mouse mammary tumour virus (MMTV) related agent in human cancer we analysed 300 samples of human sera for the presence of antibodies to MMTV structural proteins. All sera were tested by immunoblotting to achieve high specificity. Out of 300 sera, 22 reacted with transframe protein p30, 16 with the ribonucleoprotein p14, six with the envelope glycoprotein gp52 and three with the major core protein p27. Reactivities to p30 and p14 were observed in sera from cancer patients and healthy controls; reactivities to p27 and gp52 predominated in sera of cancer patients. Sera frequently reacted with a 42 kDa protein which is a cellular contaminant of the virus.

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Year:  1989        PMID： 2553093      PMCID： PMC2247107          DOI： 10.1038/bjc.1989.315

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  21 in total

1.  THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors:  F C GREENWOOD; W M HUNTER; J S GLOVER
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

2.  Electrophoretic transfer of proteins and nucleic acids from slab gels to diazobenzyloxymethyl cellulose or nitrocellulose sheets.

Authors:  M Bittner; P Kupferer; C F Morris
Journal:  Anal Biochem       Date:  1980-03-01       Impact factor: 3.365

3.  Antibody reacting with the murine mammary tumor virus in the serum of patients with breast carcinoma: a possible serological detection method for breast carcinoma.

Authors:  W D Holder; S A Wells
Journal:  Cancer Res       Date:  1983-01       Impact factor: 12.701

4.  Detection and cloning of human DNA sequences related to the mouse mammary tumor virus genome.

Authors:  R Callahan; W Drohan; S Tronick; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

5.  Antibodies reactive with the mouse mammary tumor virus in sera of breast cancer patients.

Authors:  S S Witkin; N H Sarkar; D W Kinne; R A Good; N K Day
Journal:  Int J Cancer       Date:  1980-06-15       Impact factor: 7.396

6.  Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures.

Authors:  H W Snyder; E Fleissner
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

7.  Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus.

Authors:  M Barbacid; D Bolognesi; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

8.  Properties of retrovirus-like particles produced by a human breast carcinoma cell line: immunological relationship with mouse mammary tumor virus proteins.

Authors:  I Keydar; T Ohno; R Nayak; R Sweet; F Simoni; F Weiss; S Karby; R Mesa-Tejada; S Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

9.  Antibodies to mouse mammary tumor virus-related antigen in sera of patients with breast carcinoma.

Authors:  M Tomana; A H Kajdos; W Niedermeier; W J Durkin; J Mestecky
Journal:  Cancer       Date:  1981-06-01       Impact factor: 6.860

10.  Antibodies reactive with murine mammary tumor virus in sera of patients with breast cancer: geographic and family studies.

Authors:  N K Day; S S Witkin; N H Sarkar; D Kinne; D J Jussawalla; A Levin; C C Hsia; N Geller; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205
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  4 in total

1.  Immunological quantification of RecA protein in cell extracts of E. coli after exposure to chemical mutagens or UV radiation.

Authors:  I Fridrichová; A Kovarík; O Rosskopfová
Journal:  Folia Microbiol (Praha)       Date:  1992       Impact factor: 2.099

Review 2.  Mouse Mammary Tumour Virus (MMTV) in Human Breast Cancer-The Value of Bradford Hill Criteria.

Authors:  James S Lawson; Wendy K Glenn
Journal:  Viruses       Date:  2022-03-30       Impact factor: 5.818

3.  Prevalence of serologic reactivity against four strains of mouse mammary tumour virus among US women with breast cancer.

Authors:  J J Goedert; C S Rabkin; S R Ross
Journal:  Br J Cancer       Date:  2006-02-27       Impact factor: 7.640

Review 4.  Evidence for a causal role by mouse mammary tumour-like virus in human breast cancer.

Authors:  James S Lawson; Wendy K Glenn
Journal:  NPJ Breast Cancer       Date:  2019-11-07
  4 in total

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