Literature DB >> 25530455

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis.

Takahiro Ugai1, Atsushi Minami, Ryuya Fujii, Mizuki Tanaka, Hiroki Oguri, Katsuya Gomi, Hideaki Oikawa.   

Abstract

A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

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Year:  2015        PMID： 25530455     DOI： 10.1039/c4cc09512j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

Authors:  Zhenjian Lin; Sujal Phadke; Zhenyu Lu; Sinem Beyhan; May H Abdel Aziz; Chris Reilly; Eric W Schmidt
Journal:  J Nat Prod       Date:  2018-12-03       Impact factor: 4.050

2.  Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences.

Authors:  Shota Nagamine; Chengwei Liu; Jumpei Nishishita; Takuto Kozaki; Kaho Sogahata; Yoshiro Sato; Atsushi Minami; Taro Ozaki; Claudia Schmidt-Dannert; Jun-Ichi Maruyama; Hideaki Oikawa
Journal:  Appl Environ Microbiol       Date:  2019-07-18       Impact factor: 4.792

Review 3.  Recent advances of Diels-Alderases involved in natural product biosynthesis.

Authors:  Atsushi Minami; Hideaki Oikawa
Journal:  J Antibiot (Tokyo)       Date:  2016-06-15       Impact factor: 2.649

4.  Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.

Authors:  Man-Cheng Tang; Curt R Fischer; Jason V Chari; Dan Tan; Sundari Suresh; Angela Chu; Molly Miranda; Justin Smith; Zhuan Zhang; Neil K Garg; Robert P St Onge; Yi Tang
Journal:  J Am Chem Soc       Date:  2019-05-10       Impact factor: 15.419

5.  Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis.

Authors:  U R Awodi; J L Ronan; J Masschelein; E L C de Los Santos; G L Challis
Journal:  Chem Sci       Date:  2016-08-22       Impact factor: 9.825

6.  Diels-Alder Reactions During the Biosynthesis of Sorbicillinoids.

Authors:  Lukas Kahlert; Eman F Bassiony; Russell J Cox; Elizabeth J Skellam
Journal:  Angew Chem Int Ed Engl       Date:  2020-02-04       Impact factor: 15.336

7.  Heterologous production of fungal natural products: Reconstitution of biosynthetic gene clusters in model host Aspergillus oryzae.

Authors:  Hideaki Oikawa
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2020       Impact factor: 3.493

8.  Differential Regulation and Production of Secondary Metabolites among Isolates of the Fungal Wheat Pathogen Zymoseptoria tritici.

Authors:  M Amine Hassani; Ernest Oppong-Danquah; Alice Feurtey; Deniz Tasdemir; Eva H Stukenbrock
Journal:  Appl Environ Microbiol       Date:  2022-02-02       Impact factor: 4.792
  8 in total

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