Literature DB >> 25530307

Payment expectations for research participation among subjects who tell the truth, subjects who conceal information, and subjects who fabricate information.

Eric G Devine1, Clifford M Knapp2, Ofra Sarid-Segal2, Sean M O'Keefe2, Cale Wardell2, Morgan Baskett2, Ashley Pecchia2, Katie Ferrell2, Domenic A Ciraulo2.   

Abstract

Multiple models guide researchers' payment practices but few studies have assessed subjects' expectations for payment. Payments in excess of subjects' expectations may result in undue inducement, while payments below these expectations may be associated with exploitation. Data on subjects' payment expectations will help inform practices to avoid undue inducement and exploitation. This study examined subjects' expectations for payment for common research procedures and explored the relationship between subjects' honesty and payment expectations. One-hundred subjects who participated in two or more studies in the last year reported the minimum payment they expect for completing study procedures. They were also asked about their use of deception while screening for studies. Subjects expected $20 on average to complete the least risky and least burdensome procedure. Subjects' expectations for payment consistently increased with greater procedure risks. Subjects who denied using deception to enroll in studies refused more procedures than subjects who reported using deception. Among subjects who used deception, the rate of procedure refusal increased with procedure risks, suggesting that these subjects have some risk aversion and may act to protect themselves from undue inducement. Although subjects expect greater payments for more risky procedures, ethical considerations for limiting undue inducement may prevent researchers from meeting subjects' expectations. Subjects who use deceptive practices appear to be more risk-tolerant than subjects who deny using deception; nonetheless, these deceptive subjects also exercise some risk aversion when they refuse higher-risk procedures. These subjects may be able to protect themselves from undue inducement by refusing procedures that exceed their risk tolerance.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Research payment expectations; Research risk tolerance; Undue influence in research

Mesh:

Year:  2014        PMID: 25530307      PMCID: PMC5065068          DOI: 10.1016/j.cct.2014.12.004

Source DB:  PubMed          Journal:  Contemp Clin Trials        ISSN: 1551-7144            Impact factor:   2.226


  11 in total

1.  What's the price of a research subject? Approaches to payment for research participation.

Authors:  N Dickert; C Grady
Journal:  N Engl J Med       Date:  1999-07-15       Impact factor: 91.245

Review 2.  Money for research participation: does in jeopardize informed consent?

Authors:  C Grady
Journal:  Am J Bioeth       Date:  2001       Impact factor: 11.229

3.  On paying money to research subjects: 'due' and 'undue' inducements.

Authors:  Ruth Macklin
Journal:  IRB       Date:  1981-05

4.  Perceptions of reimbursement for clinical trial participation.

Authors:  Carmen Radecki Breitkopf; Melissa Loza; Kathleen Vincent; Thomas Moench; Lawrence R Stanberry; Susan L Rosenthal
Journal:  J Empir Res Hum Res Ethics       Date:  2011-09       Impact factor: 1.742

5.  Financial compensation to adolescents for participation in biomedical research: adolescent and parent perspectives in seven studies.

Authors:  David G Scherer; Janet L Brody; Robert D Annett; Jeanne Hetter; Laura Weiss Roberts; Keely M W Cofrin
Journal:  J Pediatr       Date:  2005-04       Impact factor: 4.406

6.  Concealment and fabrication by experienced research subjects.

Authors:  Eric G Devine; Megan E Waters; Megan Putnam; Caitlin Surprise; Katie O'Malley; Courtney Richambault; Rachel L Fishman; Clifford M Knapp; Elissa H Patterson; Ofra Sarid-Segal; Chris Streeter; Laurie Colanari; Domenic A Ciraulo
Journal:  Clin Trials       Date:  2013-07-18       Impact factor: 2.486

7.  Payment of clinical research subjects.

Authors:  Christine Grady
Journal:  J Clin Invest       Date:  2005-07       Impact factor: 14.808

8.  Payment to healthy volunteers in clinical research: the research subject's perspective.

Authors:  M J Czarny; N E Kass; C Flexner; K A Carson; R K Myers; E J Fuchs
Journal:  Clin Pharmacol Ther       Date:  2010-01-20       Impact factor: 6.875

9.  Perceptions of financial payment for research participation among African-American drug users in HIV studies.

Authors:  Jacquelyn Slomka; Sheryl McCurdy; Eric A Ratliff; Sandra Timpson; Mark L Williams
Journal:  J Gen Intern Med       Date:  2007-08-01       Impact factor: 5.128

10.  Commonly performed procedures in clinical research: a benchmark for payment.

Authors:  Dinora Dominguez; Mandy Jawara; Nicole Martino; Ninet Sinaii; Christine Grady
Journal:  Contemp Clin Trials       Date:  2012-05-09       Impact factor: 2.226

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  3 in total

Review 1.  Deception in clinical trials and its impact on recruitment and adherence of study participants.

Authors:  Chuen Peng Lee; Tyson Holmes; Eric Neri; Clete A Kushida
Journal:  Contemp Clin Trials       Date:  2018-08-21       Impact factor: 2.226

2.  "Money Helps": People who inject drugs and their perceptions of financial compensation and its ethical implications.

Authors:  Roberto Abadie; Brandon Brown; Celia B Fisher
Journal:  Ethics Behav       Date:  2018-11-05

3.  Incentives and payments in pragmatic clinical trials: Scientific, ethical, and policy considerations.

Authors:  Andrew Garland; Kevin Weinfurt; Jeremy Sugarman
Journal:  Clin Trials       Date:  2021-12       Impact factor: 2.486

  3 in total

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