Carly Demopoulos1, Monica S Arroyo2, Winnie Dunn3, Zoe Strominger4, Elliott H Sherr4,5, Elysa Marco4,5,6. 1. University of California-San Francisco, Department of Radiology & Biomedical Imaging, 513 Parnassus Avenue, S362, San Francisco, CA 94143-0628. 2. Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026. 3. University of Kansas Medical Center, Department of Occupational Therapy Education, 3901 Rainbow Blvd / MS2003, Kansas City, KS 66160. 4. University of California-San Francisco, Department of Neurology, 675 Nelson Rising Lane, San Francisco, CA 94143. 5. University of California-San Francisco, Department of Pediatrics, 400 Parnassus Avenue, San Francisco, CA 94143. 6. University of California-San Francisco, Department of Psychiatry, 401 Parnassus Avenue, San Francisco, CA 94143.
Abstract
OBJECTIVE: Given reports of high pain thresholds and reduced auditory response in individuals with agenesis of the corpus callosum (AgCC), this study investigated whether affected participants report atypical experiences and behaviors on a well-established sensory processing measure. METHODS: Fourteen participants with AgCC (ages 11-59) completed the Adolescent/Adult Sensory Profile (Brown & Dunn, 2001). Sensory profile scales were classified as "Atypical" if they were more than 1 standard deviation from the mean. RESULTS: Fifty-seven percent of participants with AgCC reported reduced sensory registration as compared to an expected 16% of the normative sample. Similarly, 50% of the AgCC participants reported atypically increased auditory processing difficulties. CONCLUSIONS: Using a well-established sensory processing questionnaire, participants with AgCC reported measurable differences in multiple aspects of sensory processing. The most notable difference was in the quadrant of low sensory registration, suggesting that individuals with AgCC may require sensory information to be presented more slowly or at a higher intensity for adequate processing. The sensory modality that was most affected was the auditory system, which is consistent with increased rates of language disorders and autism spectrum disorders in this population. Understanding sensory processing in individuals with AgCC can both elucidate the role of interhemispheric transfer in the development of intact sensory processing as well as contribute to our knowledge of the role of the corpus callosum in a range of disorders in which sensory processes are impacted. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
OBJECTIVE: Given reports of high pain thresholds and reduced auditory response in individuals with agenesis of the corpus callosum (AgCC), this study investigated whether affected participants report atypical experiences and behaviors on a well-established sensory processing measure. METHODS: Fourteen participants with AgCC (ages 11-59) completed the Adolescent/Adult Sensory Profile (Brown & Dunn, 2001). Sensory profile scales were classified as "Atypical" if they were more than 1 standard deviation from the mean. RESULTS: Fifty-seven percent of participants with AgCC reported reduced sensory registration as compared to an expected 16% of the normative sample. Similarly, 50% of the AgCC participants reported atypically increased auditory processing difficulties. CONCLUSIONS: Using a well-established sensory processing questionnaire, participants with AgCC reported measurable differences in multiple aspects of sensory processing. The most notable difference was in the quadrant of low sensory registration, suggesting that individuals with AgCC may require sensory information to be presented more slowly or at a higher intensity for adequate processing. The sensory modality that was most affected was the auditory system, which is consistent with increased rates of language disorders and autism spectrum disorders in this population. Understanding sensory processing in individuals with AgCC can both elucidate the role of interhemispheric transfer in the development of intact sensory processing as well as contribute to our knowledge of the role of the corpus callosum in a range of disorders in which sensory processes are impacted. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
Authors: Yolanda C Lau; Leighton B N Hinkley; Polina Bukshpun; Zoe A Strominger; Mari L J Wakahiro; Simon Baron-Cohen; Carrie Allison; Bonnie Auyeung; Rita J Jeremy; Srikantan S Nagarajan; Elliott H Sherr; Elysa J Marco Journal: J Autism Dev Disord Date: 2013-05
Authors: Elysa J Marco; Kathryn M Harrell; Warren S Brown; Susanna S Hill; Rita J Jeremy; Joel H Kramer; Elliott H Sherr; Lynn K Paul Journal: J Int Neuropsychol Soc Date: 2012-03-06 Impact factor: 2.892
Authors: Teresa Tavassoli; Anne Brandes-Aitken; Robyn Chu; Lisa Porter; Sarah Schoen; Lucy Jane Miller; Molly Rae Gerdes; Julia Owen; Pratik Mukherjee; Elysa J Marco Journal: Mol Autism Date: 2019-02-04 Impact factor: 7.509