Literature DB >> 25527157

Effect of Golgi phosphoprotein 2 (GOLPH2/GP73) on autophagy in human hepatocellular carcinoma HepG2 cells.

Yuan-Yuan Zhou1, Jun-Chang Jiang, Jun You, Lin-Fu Zhou.   

Abstract

This study aims to investigate the effect of Golgi Protein 73 (GP73) on autophagy in human hepatoma line cells HepG2. We investigated the functional effects of GP73 on autophagy in hepatoma cell line HepG2 using immunofluoscence staining, Western blotting and real-time PCR. Our data showed that specific small interference RNA (siRNA) notably induced formation of autophagic vacuoles. In addition, upregulation of GP73 significantly inhibited formation of starvation-induced LC3-positive structures. We provide the first experimental evidence to show that GP73 may play an important role in the inhibitory regulation of autophagy. Therefore, our data suggest a new molecular mechanism for GP73-related hepatoma progression.

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Year:  2014        PMID： 25527157     DOI： 10.1007/s13277-014-2974-x

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  32 in total

1.  Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption.

Authors:  Sapna Puri; Collin Bachert; Claus J Fimmel; Adam D Linstedt
Journal:  Traffic       Date:  2002-09       Impact factor: 6.215

Review 2.  Autophagy: renovation of cells and tissues.

Authors:  Noboru Mizushima; Masaaki Komatsu
Journal:  Cell       Date:  2011-11-11       Impact factor: 41.582

3.  AP1 is essential for generation of autophagosomes from the trans-Golgi network.

Authors:  Yajuan Guo; Chunmei Chang; Rui Huang; Bo Liu; Lan Bao; Wei Liu
Journal:  J Cell Sci       Date:  2012-02-10       Impact factor: 5.285

4.  Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma.

Authors:  Yilei Mao; Huayu Yang; Haifeng Xu; Xin Lu; Xinting Sang; Shunda Du; Haitao Zhao; Wang Chen; Yiyao Xu; Tianyi Chi; Zhiying Yang; Jianqiang Cai; Hui Li; Jianguo Chen; Shouxian Zhong; Smruti R Mohanti; Reynold Lopez-Soler; J Michael Millis; Jiefu Huang; Hongbing Zhang
Journal:  Gut       Date:  2010-09-28       Impact factor: 23.059

Review 5.  Autophagy: from phenomenology to molecular understanding in less than a decade.

Authors:  Daniel J Klionsky
Journal:  Nat Rev Mol Cell Biol       Date:  2007-11       Impact factor: 94.444

6.  Increased Golgi protein 73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival.

Authors:  Yongliang Sun; Huayu Yang; Yilei Mao; Haifeng Xu; Jinchun Zhang; Guangbing Li; Xin Lu; Xinting Sang; Haitao Zhao; Shouxian Zhong; Jiefu Huang; Hongbing Zhang
Journal:  J Gastroenterol Hepatol       Date:  2011-07       Impact factor: 4.029

7.  Methods in mammalian autophagy research.

Authors:  Noboru Mizushima; Tamotsu Yoshimori; Beth Levine
Journal:  Cell       Date:  2010-02-05       Impact factor: 41.582

8.  Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease.

Authors:  Raleigh D Kladney; Xiaoyen Cui; Gary A Bulla; Elizabeth M Brunt; Claus J Fimmel
Journal:  Hepatology       Date:  2002-06       Impact factor: 17.425

Review 9.  Autophagy and ethanol-induced liver injury.

Authors:  Terrence M Donohue
Journal:  World J Gastroenterol       Date:  2009-03-14       Impact factor: 5.742

10.  Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

Authors:  Takashi Itoh; Naonobu Fujita; Eiko Kanno; Akitsugu Yamamoto; Tamotsu Yoshimori; Mitsunori Fukuda
Journal:  Mol Biol Cell       Date:  2008-04-30       Impact factor: 4.138
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  5 in total

Review 1.  Recent advances of GOLM1 in hepatocellular carcinoma.

Authors:  Jiuliang Yan; Binghai Zhou; Hui Li; Lei Guo; Qinghai Ye
Journal:  Hepat Oncol       Date:  2020-06-29

Review 2.  Research progress on GP73 in malignant tumors.

Authors:  Rong Liang; Ziyu Liu; Xuemin Piao; Mingtang Zuo; Jinyan Zhang; Zhihui Liu; Yongqiang Li; Yan Lin
Journal:  Onco Targets Ther       Date:  2018-10-24       Impact factor: 4.147

3.  AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9.

Authors:  Silvia Vergarajauregui; Robert Becker; Ulrike Steffen; Maria Sharkova; Tilman Esser; Jana Petzold; Florian Billing; Michael S Kapiloff; George Schett; Ingo Thievessen; Felix B Engel
Journal:  Elife       Date:  2020-12-09       Impact factor: 8.140

4.  Golgi protein 73, hepatocellular carcinoma and other types of cancers.

Authors:  Yanan Wang; Yu-Jui Yvonne Wan
Journal:  Liver Res       Date:  2020-09-25

Review 5.  Golgi protein 73 and its diagnostic value in liver diseases.

Authors:  Yanyan Xia; Yuanying Zhang; Mengjiao Shen; Hongpan Xu; Zhiyang Li; Nongyue He
Journal:  Cell Prolif       Date:  2018-10-19       Impact factor: 6.831
  5 in total

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