Literature DB >> 25524721

Gene Therapies for Neovascular Age-Related Macular Degeneration.

Peter Pechan1, Samuel Wadsworth1, Abraham Scaria1.   

Abstract

Pathological neovascularization is a key component of the neovascular form (also known as the wet form) of age-related macular degeneration (AMD) and proliferative diabetic retinopathy. Several preclinical studies have shown that antiangiogenesis strategies are effective for treating neovascular AMD in animal models. Vascular endothelial growth factor (VEGF) is one of the main inducers of ocular neovascularization, and several clinical trials have shown the benefits of neutralizing VEGF in patients with neovascular AMD or diabetic macular edema. In this review, we summarize several preclinical and early-stage clinical trials with intraocular gene therapies, which have the potential to reduce or eliminate the repeated intravitreal injections that are currently required for the treatment of neovascular AMD.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 25524721      PMCID： PMC4484959          DOI： 10.1101/cshperspect.a017335

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  65 in total

1.  Structural basis for double-stranded RNA processing by Dicer.

Authors:  Ian J Macrae; Kaihong Zhou; Fei Li; Adrian Repic; Angela N Brooks; W Zacheus Cande; Paul D Adams; Jennifer A Doudna
Journal:  Science       Date:  2006-01-13       Impact factor: 47.728

2.  An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris.

Authors:  Magali Saint-Geniez; Tomoki Kurihara; Eiichi Sekiyama; Angel E Maldonado; Patricia A D'Amore
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-19       Impact factor: 11.205

3.  Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration.

Authors:  M Honda; T Sakamoto; T Ishibashi; H Inomata; H Ueno
Journal:  Gene Ther       Date:  2000-06       Impact factor: 5.250

4.  Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial.

Authors:  Peter A Campochiaro; Quan Dong Nguyen; Syed Mahmood Shah; Michael L Klein; Eric Holz; Robert N Frank; David A Saperstein; Anurag Gupta; J Timothy Stout; Jennifer Macko; Robert DiBartolomeo; Lisa L Wei
Journal:  Hum Gene Ther       Date:  2006-02       Impact factor: 5.695

5.  Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys.

Authors:  Chooi-May Lai; Wei-Yong Shen; Meliha Brankov; Yvonne K Y Lai; Nigel L Barnett; Shu-Yen Lee; Ian Y S Yeo; Ranjana Mathur; Joseph E S Ho; Paul Pineda; Amutha Barathi; Chong-Lye Ang; Ian J Constable; Elizabeth P Rakoczy
Journal:  Mol Ther       Date:  2005-10       Impact factor: 11.454

6.  Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.

Authors:  F R Steele; G J Chader; L V Johnson; J Tombran-Tink
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-15       Impact factor: 11.205

7.  Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.

Authors:  Anne Louise Askou; Jean-Antoine C Pournaras; Maria Pihlmann; Jesper D Svalgaard; Yvan Arsenijevic; Corinne Kostic; Toke Bek; Frederik Dagnaes-Hansen; Jacob Giehm Mikkelsen; Thomas Gryesten Jensen; Thomas J Corydon
Journal:  J Gene Med       Date:  2012-11       Impact factor: 4.565

8.  Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.

Authors:  Jeffrey S Heier; David M Brown; Victor Chong; Jean-Francois Korobelnik; Peter K Kaiser; Quan Dong Nguyen; Bernd Kirchhof; Allen Ho; Yuichiro Ogura; George D Yancopoulos; Neil Stahl; Robert Vitti; Alyson J Berliner; Yuhwen Soo; Majid Anderesi; Georg Groetzbach; Bernd Sommerauer; Rupert Sandbrink; Christian Simader; Ursula Schmidt-Erfurth
Journal:  Ophthalmology       Date:  2012-10-17       Impact factor: 12.079

9.  EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV.

Authors:  K S Balaggan; K Binley; M Esapa; R E MacLaren; S Iqball; Y Duran; R A Pearson; O Kan; S E Barker; A J Smith; J W B Bainbridge; S Naylor; R R Ali
Journal:  Gene Ther       Date:  2006-06-13       Impact factor: 5.250

10.  Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors.

Authors:  Magali Saint-Geniez; Arindel S R Maharaj; Tony E Walshe; Budd A Tucker; Eiichi Sekiyama; Tomoki Kurihara; Diane C Darland; Michael J Young; Patricia A D'Amore
Journal:  PLoS One       Date:  2008-11-03       Impact factor: 3.240
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  2 in total

1.  Associations of microRNAs, Angiogenesis-Regulating Factors and CFH Y402H Polymorphism-An Attempt to Search for Systemic Biomarkers in Age-Related Macular Degeneration.

Authors:  Zofia Ulańczyk; Anna Sobuś; Karolina Łuczkowska; Aleksandra Grabowicz; Katarzyna Mozolewska-Piotrowska; Krzysztof Safranow; Miłosz Piotr Kawa; Andrzej Pałucha; Mariusz Krawczyk; Piotr Sikora; Ewa Matczyńska; Bogusław Machaliński; Anna Machalińska
Journal:  Int J Mol Sci       Date:  2019-11-15       Impact factor: 5.923

Review 2.  Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels.

Authors:  Yue Ruan; Subao Jiang; Adrian Gericke
Journal:  Int J Mol Sci       Date:  2021-01-28       Impact factor: 5.923
  2 in total

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