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Literature DB >> 33525498

Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels.

Yue Ruan¹, Subao Jiang¹, Adrian Gericke¹.

Abstract

Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: age-related macular degeneration; choroidal vascular dysfunction; dysregulated lipid metabolism; genetic factor; oxidative stress; pathogenesis

Year: 2021 PMID： 33525498 PMCID： PMC7866075 DOI： 10.3390/ijms22031296

Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923

213 in total

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Authors: Paul Mitchell; Suriya Foran
Journal: Arch Ophthalmol Date: 2005-11

2. Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study.

Authors: Jennifer S L Tan; Paul Mitchell; Elena Rochtchina; Jie Jin Wang
Journal: Am J Ophthalmol Date: 2006-12-20 Impact factor: 5.258

3. Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression.

Authors: Chuan-Ming Li; Mark E Clark; Melissa F Chimento; Christine A Curcio
Journal: Invest Ophthalmol Vis Sci Date: 2006-07 Impact factor: 4.799

4. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope.

Authors: A von Rückmann; F W Fitzke; A C Bird
Journal: Invest Ophthalmol Vis Sci Date: 1997-02 Impact factor: 4.799

Review 5. Updates on the Epidemiology of Age-Related Macular Degeneration.

Authors: Jost B Jonas; Chui Ming Gemmy Cheung; Songhomitra Panda-Jonas
Journal: Asia Pac J Ophthalmol (Phila) Date: 2017-09-14

6. IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation.

Authors: Haibo Wang; Aniket Ramshekar; Eric Kunz; David B Sacks; M Elizabeth Hartnett
Journal: Angiogenesis Date: 2020-08-11 Impact factor: 9.596

7. NADPH oxidase 4 mediates insulin-stimulated HIF-1α and VEGF expression, and angiogenesis in vitro.

Authors: Dan Meng; Aihong Mei; Junxu Liu; Xueling Kang; Xianglin Shi; Ruizhe Qian; Sifeng Chen
Journal: PLoS One Date: 2012-10-29 Impact factor: 3.240

Review 8. NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.

Authors: Pu Hong; Ruo-Nan Gu; Feng-Xian Li; Xiao-Xing Xiong; Wen-Bin Liang; Zhi-Jian You; Hong-Fei Zhang
Journal: J Neuroinflammation Date: 2019-06-07 Impact factor: 8.322

9. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration.

Authors: Jennyfer Zerbib; Johanna M Seddon; Florence Richard; Robyn Reynolds; Nicolas Leveziel; Pascale Benlian; Patrick Borel; Josué Feingold; Arnold Munnich; Gisèle Soubrane; Josseline Kaplan; Jean-Michel Rozet; Eric H Souied
Journal: PLoS One Date: 2009-10-05 Impact factor: 3.240

15 in total

Review 1. Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age.

Authors: T B Feldman; A E Dontsov; M A Yakovleva; M A Ostrovsky
Journal: Biophys Rev Date: 2022-08-08

2. The Antisenescence Effect of Exosomes from Human Adipose-Derived Stem Cells on Skin Fibroblasts.

Authors: Ji-An Guo; Pi-Jun Yu; Dong-Qin Yang; Wei Chen
Journal: Biomed Res Int Date: 2022-06-29 Impact factor: 3.246

Review 3. The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.

Authors: Daire John Hurley; Caoimhe Normile; Mustapha Irnaten; Colm O'Brien
Journal: Antioxidants (Basel) Date: 2022-04-29

Review 4. Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease.

Authors: Caterina Toma; Stefano De Cillà; Aurelio Palumbo; Divya Praveen Garhwal; Elena Grossini
Journal: Antioxidants (Basel) Date: 2021-04-23

Review 5. Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α.

Authors: Janusz Blasiak; Joanna Szczepanska; Michal Fila; Elzbieta Pawlowska; Kai Kaarniranta
Journal: Int J Mol Sci Date: 2021-07-03 Impact factor: 5.923

Review 6. Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications.

Authors: Todd McLaughlin; Andy Medina; Jacob Perkins; Maria Yera; Joshua J Wang; Sarah X Zhang
Journal: Mol Neurodegener Date: 2022-03-28 Impact factor: 14.195