Donghyun Kim1, Wontaek Kim1, Joohye Lee1, Yongkan Ki1, Byungjoo Lee2, Kyusup Cho2, Seongjang Kim3, Jiho Nam4, Jinchoon Lee5, Dongwon Kim1. 1. Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea. 2. Department of Otorhinolaryngology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea. 3. Department of Nuclear Medicine, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea. 4. Department of Radiation Oncology, Yangsan Pusan National University Hospital, Yangsan, Korea. 5. Department of Otorhinolaryngology, Yangsan Pusan National University Hospital, Yangsan, Korea.
Abstract
BACKGROUND: The purpose of this study was to determine whether the maximum standardized uptake value (SUVmax) of the primary tumor on pretreatment (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) has prognostic significance in patients with adenoid cystic carcinoma (ACC) of the head and neck. METHODS: A retrospective review was carried out on 34 patients with ACC of the head and neck who underwent pretreatment (18)F-FDG PET imaging from June 2005 through July 2009. All patients underwent surgery with curative intent, and 26 of them received adjuvant radiotherapy (RT). RESULTS: When subjects were stratified into 2 groups according to a cutoff value for SUVmax of 4.15, the risk of distant metastasis was significantly high in patients with high SUVmax (p = .014). Multivariate analysis showed that high SUVmax and histologic grade 3 were independent poor prognostic factors for distant metastasis-free and disease-free survival. CONCLUSION: Pretreatment SUVmax of the primary tumor is an independent prognostic factor in patients with ACC of the head and neck.
BACKGROUND: The purpose of this study was to determine whether the maximum standardized uptake value (SUVmax) of the primary tumor on pretreatment (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) has prognostic significance in patients with adenoid cystic carcinoma (ACC) of the head and neck. METHODS: A retrospective review was carried out on 34 patients with ACC of the head and neck who underwent pretreatment (18)F-FDG PET imaging from June 2005 through July 2009. All patients underwent surgery with curative intent, and 26 of them received adjuvant radiotherapy (RT). RESULTS: When subjects were stratified into 2 groups according to a cutoff value for SUVmax of 4.15, the risk of distant metastasis was significantly high in patients with high SUVmax (p = .014). Multivariate analysis showed that high SUVmax and histologic grade 3 were independent poor prognostic factors for distant metastasis-free and disease-free survival. CONCLUSION: Pretreatment SUVmax of the primary tumor is an independent prognostic factor in patients with ACC of the head and neck.
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