Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 DNA duplex with the potential to change handedness after every half a turn.

Literature DB >> 2552407

DNA duplex with the potential to change handedness after every half a turn.

S K Brahmachari¹, R K Mishra, R Bagga, N Ramesh.

Abstract

Polymorphic forms of the DNA duplex with long stretches of structural monotony are known. Several alternating purine-pyrimidine sequences have been shown to adopt left-handed Z-conformation. We report a DNA sequence d(CGCGCGATCGAT)n exhibiting alternating right-handed B and left-handed Z helical conformation after every half a turn. Further, this unusual conformation with change in handedness after every six base pairs was induced at physiological superhelical density.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2552407 PMCID： PMC334807 DOI： 10.1093/nar/17.18.7273

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

38 in total

1. A possible conformation for double-stranded polynucleotides.

Authors: G A Rodley; R S Scobie; R H Bates; R M Lewitt
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors: F M Pohl; T M Jovin
Journal: J Mol Biol Date: 1972-06-28 Impact factor: 5.469

DNA duplex with the potential to change handedness after every half a turn.

1. A possible conformation for double-stranded polynucleotides.

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

3. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

4. The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

5. Conformational flexibility of DNA: polymorphism and handedness.

6. Reversal of handedness in DNA: a stable link between RU and LZ helices.

7. Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresis.

8. Some implications of an alternative structure for DNA.

9. Purification and characterization of wheat germ DNA topoisomerase I (nicking-closing enzyme).

10. Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1. Supercoil-induced unusual DNA structures as transcriptional block.

2. Intramolecular triplex potential sequence within a gene down regulates its expression in vivo.