CONTEXT: The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy. OBJECTIVES: We analyzed the predictive value of the dynamics of these antibodies on clinical responses. MATERIALS AND METHODS: The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimens RESULTS: In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses. CONCLUSIONS: Antibody titer dynamics was useful for predicting clinical responses.
CONTEXT: The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy. OBJECTIVES: We analyzed the predictive value of the dynamics of these antibodies on clinical responses. MATERIALS AND METHODS: The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimens RESULTS: In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses. CONCLUSIONS: Antibody titer dynamics was useful for predicting clinical responses.
Entities:
Keywords:
Cyclophospamide; membranous nephropathy; renal disease; rituximab; type M phospholipase A2 antibodies
Authors: An S De Vriese; Richard J Glassock; Karl A Nath; Sanjeev Sethi; Fernando C Fervenza Journal: J Am Soc Nephrol Date: 2016-10-24 Impact factor: 10.121
Authors: Christine Barrett; Lisa C Willcocks; Rachel B Jones; Ruth M Tarzi; Robert B Henderson; Gengqian Cai; Sophie I Gisbert; Alexandra S Belson; Caroline O Savage Journal: Nephrol Dial Transplant Date: 2020-04-01 Impact factor: 5.992