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Literature DB >> 25517371

Cell polarity: netrin calms an excitable system.

Abstract

In a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates through basement membranes towards a polarity cue provided by netrin. A new study reveals that the anchor cell polarity network can break symmetry and oscillate in the absence of netrin, suggesting the presence of interlinked positive and negative feedback loops, which are common in polarity pathways.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 25517371 PMCID： PMC5929466 DOI： 10.1016/j.cub.2014.09.042

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

18 in total

1. UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons.

Authors: Hannah M Teichmann; Kang Shen
Journal: Nat Neurosci Date: 2010-12-26 Impact factor: 24.884

Review 2. Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.

Authors: Wonhee Jang; Richard H Gomer
Journal: J R Soc Interface Date: 2008-08-06 Impact factor: 4.118

3. Cdc42 explores the cell periphery for mate selection in fission yeast.

Authors: Felipe O Bendezú; Sophie G Martin
Journal: Curr Biol Date: 2012-11-29 Impact factor: 10.834

4. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.

Authors: E M Hedgecock; J G Culotti; D H Hall
Journal: Neuron Date: 1990-01 Impact factor: 17.173

1. Oscillatory signatures underlie growth regimes in Arabidopsis pollen tubes: computational methods to estimate tip location, periodicity, and synchronization in growing cells.

Authors: Daniel S C Damineli; Maria Teresa Portes; José A Feijó
Journal: J Exp Bot Date: 2017-06-01 Impact factor: 6.992

1 in total

Cell polarity: netrin calms an excitable system.

1. UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons.

Review 2. Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.

3. Cdc42 explores the cell periphery for mate selection in fission yeast.

4. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.

5. Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes.

6. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans.

Review 7. Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.

Review 8. Design principles of biochemical oscillators.

9. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.

10. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.

1. Oscillatory signatures underlie growth regimes in Arabidopsis pollen tubes: computational methods to estimate tip location, periodicity, and synchronization in growing cells.