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Literature DB >> 25512793

Sirtuins as novel players in the pathogenesis of diabetes mellitus.

Kultigin Turkmen¹, Ali Karagoz¹, Adem Kucuk¹.

Abstract

Diabetes mellitus (DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD(+) dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus.

Entities: Chemical Disease

Keywords: Diabetes mellitus; Hyperglycemia; Hyperlipidemia; Resveratrol; Sirtuins

Year: 2014 PMID： 25512793 PMCID： PMC4265877 DOI： 10.4239/wjd.v5.i6.894

Source DB: PubMed Journal: World J Diabetes ISSN： 1948-9358

72 in total

1. SIRT6 promotes DNA repair under stress by activating PARP1.

Authors: Zhiyong Mao; Christopher Hine; Xiao Tian; Michael Van Meter; Matthew Au; Amita Vaidya; Andrei Seluanov; Vera Gorbunova
Journal: Science Date: 2011-06-17 Impact factor: 47.728

Review 2. Nephroprotective action of sirtuin 1 (SIRT1).

Authors: Dorota Polak-Jonkisz; Krystyna Laszki-Szcząchor; Leopold Rehan; Witold Pilecki; Henryk Filipowski; Małgorzata Sobieszczańska
Journal: J Physiol Biochem Date: 2013-06-23 Impact factor: 4.158

3. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Authors: Joseph T Rodgers; Carlos Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Journal: Nature Date: 2005-03-03 Impact factor: 49.962

4. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

Review 5. NAD+ and vitamin B3: from metabolism to therapies.

Authors: Anthony A Sauve
Journal: J Pharmacol Exp Ther Date: 2007-12-28 Impact factor: 4.030

6. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.

Authors: Hiroshi Inoue; Wataru Ogawa; Michitaka Ozaki; Sanae Haga; Michihiro Matsumoto; Kensuke Furukawa; Naoko Hashimoto; Yoshiaki Kido; Toshiyuki Mori; Hiroshi Sakaue; Kiyoshi Teshigawara; Shiyu Jin; Haruhisa Iguchi; Ryuji Hiramatsu; Derek LeRoith; Kiyoshi Takeda; Shizuo Akira; Masato Kasuga
Journal: Nat Med Date: 2004-01-11 Impact factor: 53.440

Review 7. The Sir2 family of protein deacetylases.

Authors: Gil Blander; Leonard Guarente
Journal: Annu Rev Biochem Date: 2004 Impact factor: 23.643

8. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.

Authors: Jiandi Zhang
Journal: J Biol Chem Date: 2007-09-27 Impact factor: 5.157

9. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.

Authors: Vijay K Yechoor; Mary-Elizabeth Patti; Kohjiro Ueki; Palle G Laustsen; Robert Saccone; Ravi Rauniyar; C Ronald Kahn
Journal: Proc Natl Acad Sci U S A Date: 2004-11-16 Impact factor: 11.205

10. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Authors: Laura Bordone; Maria Carla Motta; Frederic Picard; Ashley Robinson; Ulupi S Jhala; Javier Apfeld; Thomas McDonagh; Madeleine Lemieux; Michael McBurney; Akos Szilvasi; Erin J Easlon; Su-Ju Lin; Leonard Guarente
Journal: PLoS Biol Date: 2005-12-27 Impact factor: 8.029

23 in total

1. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of α-crystallin in mouse lenses.

Authors: Sandip K Nandi; Rooban B Nahomi; Peter S Harris; Cole R Michel; Kristofer S Fritz; Ram H Nagaraj
Journal: Exp Eye Res Date: 2019-03-05 Impact factor: 3.467

2. Resveratrol: Evidence for Its Nephroprotective Effect in Diabetic Nephropathy.

Authors: Vemana Gowd; Qingzheng Kang; Qi Wang; Qiang Wang; Feng Chen; Ka-Wing Cheng
Journal: Adv Nutr Date: 2020-11-16 Impact factor: 8.701

Review 3. Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies.

Authors: Jasvinder Singh Bhatti; Gurjit Kaur Bhatti; P Hemachandra Reddy
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2016-11-09 Impact factor: 5.187

Review 4. Immune Cell Regulatory Pathways Unexplored as Host-Directed Therapeutic Targets for Mycobacterium tuberculosis: An Opportunity to Apply Precision Medicine Innovations to Infectious Diseases.

Authors: Robert N Mahon; Richard Hafner
Journal: Clin Infect Dis Date: 2015-10-15 Impact factor: 9.079