Literature DB >> 2550784

Alpha-1-adrenergic stimulation of phosphoinositide breakdown in cultured neonatal rat ventricular myocytes.

J T Meij1, J M Lamers.   

Abstract

The regulation of and the intracellular events following alpha 1-adrenergic receptor stimulation in the myocardium still remain to be disclosed. The effect of alpha 1-adrenergic stimulation on phosphoinositide breakdown was studied in cultured neonatal rat ventricular myocytes. Phenylephrine (30 microM) stimulated inositolphosphates formation, but only in the presence of 10 mM LiCl this could be measured. The increase was antagonized by prazosin (1 microM) but not by propranolol (1 microM). The variability in proportional distribution of the three inositolphosphates is discussed.

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Year:  1989        PMID： 2550784     DOI： 10.1007/BF00223426

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  10 in total

1.  Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart.

Authors:  W Schmitz; H Scholz; J Scholz; M Steinfath; M Lohse; J Puurunen; U Schwabe
Journal:  Eur J Pharmacol       Date:  1987-02-24       Impact factor: 4.432

Review 2.  Existence and functional role of alpha 1-adrenoceptors in the mammalian heart.

Authors:  R Brückner; A Mügge; H Scholz
Journal:  J Mol Cell Cardiol       Date:  1985-07       Impact factor: 5.000

Review 3.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

4.  Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

Authors:  M A Movsesian; M Nishikawa; R S Adelstein
Journal:  J Biol Chem       Date:  1984-07-10       Impact factor: 5.157

5.  Changes in cytoplasmic and lysosomal enzyme activities in cultured rat heart cells: the relationship to cell differentiation and cell population in culture.

Authors:  S Yagev; M Heller; A Pinson
Journal:  In Vitro       Date:  1984-12

6.  Inositol phosphate production following alpha 1-adrenergic, muscarinic or electrical stimulation in isolated rat heart.

Authors:  J Poggioli; J C Sulpice; G Vassort
Journal:  FEBS Lett       Date:  1986-10-06       Impact factor: 4.124

7.  Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

Authors:  M J Berridge; C P Downes; M R Hanley
Journal:  Biochem J       Date:  1982-09-15       Impact factor: 3.857

8.  Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.

Authors:  J H Brown; I L Buxton; L L Brunton
Journal:  Circ Res       Date:  1985-10       Impact factor: 17.367

9.  Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle.

Authors:  P Volpe; G Salviati; F Di Virgilio; T Pozzan
Journal:  Nature       Date:  1985 Jul 25-31       Impact factor: 49.962

10.  Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.

Authors:  M Hirata; E Suematsu; T Hashimoto; T Hamachi; T Koga
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857
  10 in total
  6 in total

1.  Discrete interactions between phosphatidylethanolamine-N-methylation and phosphatidylinositolbisphosphate hydrolysis in rat myocardium.

Authors:  J T Meij; G Paolillo; K Bezstarosti; P D Verdouw; V Panagia; J M Lamers
Journal:  Mol Cell Biochem       Date:  1989-10-31       Impact factor: 3.396

2.  Suppression of inositol phosphate release by cardiac myocytes isolated from fish oil-fed pigs.

Authors:  S S Nair; J Leitch; M L Garg
Journal:  Mol Cell Biochem       Date:  2000-12       Impact factor: 3.396

3.  Intravenously injected [1-14C]arachidonic acid targets phospholipids, and [1-14C]palmitic acid targets neutral lipids in hearts of awake rats.

Authors:  E J Murphy; T A Rosenberger; C B Patrick; S I Rapoport
Journal:  Lipids       Date:  2000-08       Impact factor: 1.880

4.  Phorbol ester and the actions of phosphatidylinositol 4,5-bisphosphate specific phospholipase C and protein kinase C in microsomes prepared from cultured cardiomyocytes.

Authors:  J T Meij; K Bezstarosti; V Panagia; J M Lamers
Journal:  Mol Cell Biochem       Date:  1991-06-26       Impact factor: 3.396

Review 5.  Occurrence and functions of the phosphatidylinositol cycle in the myocardium.

Authors:  J M Lamers; D H Dekkers; K Bezstarosti; J T Meij; H A van Heugten
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396

6.  The effect of ischaemia-reperfusion on [3H]inositol phosphates and ins(1,4,5)P3 levels in cardiac atria and ventricles--a comparative study.

Authors:  R Mouton; S Genade; B Huisamen; M Malan; A Lochner
Journal:  Mol Cell Biochem       Date:  1992-10-07       Impact factor: 3.396
  6 in total

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