Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor.

Literature DB >> 25506897

Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor.

Zhongyong Wang, Sicong Zhang, Timothy L Siu, Suyun Huang¹.

Abstract

Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition (EMT), invasion, angiogenesis and upregulating Wnt/β-catenin signalling. Our recent experimental findings are also summarized to prove that FoxM1 is a novel therapeutic target against GBM.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25506897 PMCID： PMC4380124 DOI： 10.2174/1381612821666141211115949

Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116

51 in total

1. FoxM1 is required for execution of the mitotic programme and chromosome stability.

Authors: Jamila Laoukili; Matthijs R H Kooistra; Alexandra Brás; Jos Kauw; Ron M Kerkhoven; Ashby Morrison; Hans Clevers; René H Medema
Journal: Nat Cell Biol Date: 2005-01-16 Impact factor: 28.824

Review 2. The emerging roles of forkhead box (Fox) proteins in cancer.

Authors: Stephen S Myatt; Eric W-F Lam
Journal: Nat Rev Cancer Date: 2007-11 Impact factor: 60.716

3. Down-regulation of FoxM1 leads to the inhibition of the epithelial-mesenchymal transition in gastric cancer cells.

Authors: Lifeng Miao; Xianze Xiong; Yixin Lin; Yao Cheng; Jiong Lu; Jie Zhang; Nansheng Cheng
Journal: Cancer Genet Date: 2014-02-27

4. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.

Authors: Jianfei Xue; Xia Lin; Wen-Tai Chiu; Yao-Hui Chen; Guanzhen Yu; Mingguang Liu; Xin-Hua Feng; Raymond Sawaya; René H Medema; Mien-Chie Hung; Suyun Huang
Journal: J Clin Invest Date: 2014-01-02 Impact factor: 14.808

5. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation.

Authors: Xun Jin; Hee-Young Jeon; Kyeung Min Joo; Jun-Kyum Kim; Juyoun Jin; Sung Hak Kim; Bong Gu Kang; Samuel Beck; Se Jeong Lee; Joong Kyu Kim; Ae-Kyung Park; Woong-Yang Park; Yun-Jaie Choi; Do-Hyun Nam; Hyunggee Kim
Journal: Cancer Res Date: 2011-03-01 Impact factor: 12.701

6. Increased FoxM1 expression is a target for metformin in the suppression of EMT in prostate cancer.

Authors: Yiru Wang; Binwei Yao; Yu Wang; Mingbo Zhang; Shuai Fu; Hanjing Gao; Ruiyun Peng; Lingqiang Zhang; Jie Tang
Journal: Int J Mol Med Date: 2014-03-20 Impact factor: 4.101

7. Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer.

Authors: Fei-Fei Kong; Zeng-Qiang Qu; Hai-Hua Yuan; Jiong-Yi Wang; Mei Zhao; Yue-Hui Guo; Jing Shi; Xiao-Di Gong; You-Long Zhu; Feng Liu; Wen-Ying Zhang; Bin Jiang
Journal: Oncol Rep Date: 2014-04-04 Impact factor: 3.906

8. Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts.

Authors: J Graeme Hodgson; Ru-Fang Yeh; Amrita Ray; Nicholas J Wang; Ivan Smirnov; Mamie Yu; Sujatmi Hariono; Joachim Silber; Heidi S Feiler; Joe W Gray; Paul T Spellman; Scott R Vandenberg; Mitchel S Berger; C David James
Journal: Neuro Oncol Date: 2009-01-12 Impact factor: 12.300

Review 9. Angiogenesis in cancer, vascular, rheumatoid and other disease.

Authors: J Folkman
Journal: Nat Med Date: 1995-01 Impact factor: 53.440

10. FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression.

Authors: Muhammad K Mirza; Ying Sun; Yidan D Zhao; Hari-Hara S K Potula; Randall S Frey; Steven M Vogel; Asrar B Malik; You-Yang Zhao
Journal: J Exp Med Date: 2010-07-26 Impact factor: 14.307

25 in total

Review 10. Molecular Determinants of Malignant Brain Cancers: From Intracellular Alterations to Invasion Mediated by Extracellular Vesicles.

Authors: Gabriella Schiera; Carlo Maria Di Liegro; Italia Di Liegro
Journal: Int J Mol Sci Date: 2017-12-20 Impact factor: 5.923

Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor.

1. FoxM1 is required for execution of the mitotic programme and chromosome stability.

Review 2. The emerging roles of forkhead box (Fox) proteins in cancer.

3. Down-regulation of FoxM1 leads to the inhibition of the epithelial-mesenchymal transition in gastric cancer cells.

4. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.

5. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation.

6. Increased FoxM1 expression is a target for metformin in the suppression of EMT in prostate cancer.

7. Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer.

8. Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts.

Review 9. Angiogenesis in cancer, vascular, rheumatoid and other disease.

10. FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression.

1. MicroRNA miR-1249 downregulates adenomatous polyposis coli 2 expression and promotes glioma cells proliferation.

2. PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance.

Review 3. The Unwanted Cell Migration in the Brain: Glioma Metastasis.

4. IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.

5. Tumor-promoting function of PIMREG in glioma by activating the β-catenin pathway.

6. The EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells.

7. Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.

8. FoxM1 is a promising candidate target in the treatment of breast cancer.

9. Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen.

Review 10. Molecular Determinants of Malignant Brain Cancers: From Intracellular Alterations to Invasion Mediated by Extracellular Vesicles.