| Literature DB >> 28478595 |
Xue Tao Qi1,2,3,4, Jiang Shan Zhan1,2,3,4, Li Ming Xiao1,2,3,4, Lina Li5,6,7,8,9,10, Han Xiao Xu1,2,3,4,11, Zi Bing Fu1,2,3,4, Yan Hao Zhang1,2,3,4, Jing Zhang12,13, Xi Hua Jia1,2,3,4,14,15, Guo Ge1,2,3,4,11, Rui Chao Chai1,2,3,4,14,15, Kai Gao1,2,3,4,16, Albert Cheung Hoi Yu17,18,19,20,21,22,23.
Abstract
Cell migration is identified as a highly orchestrated process. It is a fundamental and essential phenomenon underlying tissue morphogenesis, wound healing, and immune response. Under dysregulation, it contributes to cancer metastasis. Brain is considered to be the most complex organ in human body containing many types of neural cells with astrocytes playing crucial roles in monitoring both physiological and pathological functions. Astrocytoma originates from astrocytes and its most malignant type is glioblastoma multiforme (WHO Grade IV astrocytoma), which is capable to infiltrate widely into the neighboring brain tissues making a complete resection of tumors impossible. Very recently, we have reviewed the mechanisms for astrocytes in migration. Given the fact that astrocytoma shares many histological features with astrocytes, we therefore attempt to review the mechanisms for glioma cells in migration and compare them to normal astrocytes, hoping to obtain a better insight into the dysregulation of migratory mechanisms contributing to their metastasis in the brain.Entities:
Keywords: Astrocyte; Astrocytoma; Cell migration; Glioblastoma multiforme; Glioma; Metastasis
Mesh：
Year: 2017 PMID： 28478595 DOI： 10.1007/s11064-017-2272-2
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996