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Literature DB >> 25504623

Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene.

Tianyue Jiang¹, Wujin Sun, Qiuwen Zhu, Nancy A Burns, Saad A Khan, Ran Mo, Zhen Gu.

Abstract

A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL and DOX can be sequentially released toward the plasma membrane and nucleus, respectively.

Entities: CellLine Chemical Disease Gene Species

Keywords: cytokine; drug delivery; furin; graphene oxide; nanomedicine

Mesh：

Substances：

Year: 2014 PMID： 25504623 PMCID： PMC5769919 DOI： 10.1002/adma.201404498

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

51 in total

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Authors: Marwa Mlaouah; Bahoueddine Tangour; Mohammed El Khalifi; Tijani Gharbi; Fabien Picaud
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4. Intracellular Mechanistic Understanding of 2D MoS₂ Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy.

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Journal: ACS Nano Date: 2018-03-12 Impact factor: 15.881