Literature DB >> 26122945

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

Dennis B Pacardo1, Bhanu Neupane, S Michaela Rikard, Yue Lu, Ran Mo, Sumeet R Mishra, Joseph B Tracy, Gufeng Wang, Frances S Ligler, Zhen Gu.   

Abstract

A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics.

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Year:  2015        PMID： 26122945      PMCID： PMC4998739          DOI： 10.1039/c5nr01568e

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  60 in total

1.  Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview.

Authors:  Ravi Shukla; Vipul Bansal; Minakshi Chaudhary; Atanu Basu; Ramesh R Bhonde; Murali Sastry
Journal:  Langmuir       Date:  2005-11-08       Impact factor: 3.882

2.  Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications.

Authors:  Ennio Tasciotti; Xuewu Liu; Rohan Bhavane; Kevin Plant; Ashley D Leonard; B Katherine Price; Mark Ming-Cheng Cheng; Paolo Decuzzi; James M Tour; Fredika Robertson; Mauro Ferrari
Journal:  Nat Nanotechnol       Date:  2008-03-02       Impact factor: 39.213

3.  Promises, facts and challenges for carbon nanotubes in imaging and therapeutics.

Authors:  K Kostarelos; A Bianco; M Prato
Journal:  Nat Nanotechnol       Date:  2009-09-27       Impact factor: 39.213

Review 4.  Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions.

Authors:  Alaaldin M Alkilany; Lucas B Thompson; Stefano P Boulos; Patrick N Sisco; Catherine J Murphy
Journal:  Adv Drug Deliv Rev       Date:  2011-03-21       Impact factor: 15.470

5.  First demonstration of gold nanorods-mediated photodynamic therapeutic destruction of tumors via near infra-red light activation.

Authors:  Raviraj Vankayala; Yu-Kuan Huang; Poliraju Kalluru; Chi-Shiun Chiang; Kuo Chu Hwang
Journal:  Small       Date:  2013-12-16       Impact factor: 13.281

Review 6.  Gold nanoparticles for biology and medicine.

Authors:  David A Giljohann; Dwight S Seferos; Weston L Daniel; Matthew D Massich; Pinal C Patel; Chad A Mirkin
Journal:  Angew Chem Int Ed Engl       Date:  2010-04-26       Impact factor: 15.336

Review 7.  Nanoparticle-based theranostic agents.

Authors:  Jin Xie; Seulki Lee; Xiaoyuan Chen
Journal:  Adv Drug Deliv Rev       Date:  2010-08-04       Impact factor: 15.470

8.  Cyclodextrin-modified polyethylenimine polymers for gene delivery.

Authors:  Suzie H Pun; Nathalie C Bellocq; Aijie Liu; Greg Jensen; Todd Machemer; Erlinda Quijano; Thomas Schluep; Shufen Wen; Heidrun Engler; Jeremy Heidel; Mark E Davis
Journal:  Bioconjug Chem       Date:  2004 Jul-Aug       Impact factor: 4.774

Review 9.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
Journal:  Nat Nanotechnol       Date:  2007-12       Impact factor: 39.213

Review 10.  Nanoparticle therapeutics: an emerging treatment modality for cancer.

Authors:  Mark E Davis; Zhuo Georgia Chen; Dong M Shin
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694
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  5 in total

Review 1.  Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters.

Authors:  Wei He; Guanyu Ma; Quanli Shen; Zhenghua Tang
Journal:  Nanomaterials (Basel)       Date:  2022-05-19       Impact factor: 5.719

2.  D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria.

Authors:  Xinglong Yang; Yan Dang; Jinli Lou; Huawu Shao; Xingyu Jiang
Journal:  Theranostics       Date:  2018-02-04       Impact factor: 11.556

Review 3.  Photoacoustic Drug Delivery.

Authors:  Yuqi Zhang; Jicheng Yu; Anna R Kahkoska; Zhen Gu
Journal:  Sensors (Basel)       Date:  2017-06-15       Impact factor: 3.576

4.  AlPcS4-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic® F127 nanomicellar drug carriers.

Authors:  Jing Xin; Sijia Wang; Bing Wang; Jiazhuang Wang; Jing Wang; Luwei Zhang; Bo Xin; Lijian Shen; Zhenxi Zhang; Cuiping Yao
Journal:  Int J Nanomedicine       Date:  2018-04-04

5.  Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma.

Authors:  Wenguang Gu; Tao Zhang; Junsheng Gao; Yi Wang; Dejian Li; Ziwen Zhao; Bo Jiang; Zhiwei Dong; Hui Liu
Journal:  Drug Deliv       Date:  2019-12       Impact factor: 6.419
  5 in total

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