Maria Igglezou1, Katerina Vareli2, Georgios K Georgiou3, Ioannis Sainis1, Evangelos Briasoulis4. 1. Cancer Biobank Center, University of Ioannina, Ioannina, Greece. 2. Cancer Biobank Center, University of Ioannina, Ioannina, Greece Department of Biological Applications and Technologies, University of Ioannina, Ioannina, Greece. 3. Department of Surgery, University Hospital of Ioannina, Ioannina, Greece. 4. Cancer Biobank Center, University of Ioannina, Ioannina, Greece ebriasou@otenet.gr.
Abstract
BACKGROUND: MicroRNAs are small RNA molecules that negatively regulate the expression of the majority of proteins, mainly at the post-transcriptional level. Being stable in the circulation and resistant to storage handling, they are potentially promising biomarkers. MATERIALS AND METHODS: We measured RNA levels of three microRNAs with tumorigenic or angiogenic potential (miR-155, miR-195, and miR-21) in blood samples taken from patients with early breast cancer, both preoperatively and postoperatively. RESULTS: We found that persistently elevated postoperative levels of miR-195 were detected only in patients who developed early tumor relapse and that miR-155 levels tended to increase three days postoperatively (p=0.05) and fell below baseline one month post-surgery (p<0.05). We had no major findings for miR-21. CONCLUSION: The results of this pilot study indicate a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. Copyright
BACKGROUND: MicroRNAs are small RNA molecules that negatively regulate the expression of the majority of proteins, mainly at the post-transcriptional level. Being stable in the circulation and resistant to storage handling, they are potentially promising biomarkers. MATERIALS AND METHODS: We measured RNA levels of three microRNAs with tumorigenic or angiogenic potential (miR-155, miR-195, and miR-21) in blood samples taken from patients with early breast cancer, both preoperatively and postoperatively. RESULTS: We found that persistently elevated postoperative levels of miR-195 were detected only in patients who developed early tumor relapse and that miR-155 levels tended to increase three days postoperatively (p=0.05) and fell below baseline one month post-surgery (p<0.05). We had no major findings for miR-21. CONCLUSION: The results of this pilot study indicate a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. Copyright
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