Zoran Jukic1, Zeljko Ferencic2, Petra Radulovic3, August Mijic3, Aleksandra Fucic4. 1. General Hospital "Nova Gradiska", Nova Gradiska, Croatia. 2. Children's Hospital "Srebrnjak", Zagreb, Croatia. 3. Clinical Hospital Center "Sestre Milosrdnice", Zagreb, Croatia. 4. Institute for Medical Research and Occupational Health, Zagreb, Croatia afucic@imi.hr.
Abstract
BACKGROUND/AIM: Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with inflammatory infiltrate. The aim of the present study was to investigate the presence of estrogen and androgen receptors in IFP and compare it with its proliferative loci. PATIENTS AND METHODS: The study analyzed a 79-year-old patient suffering from IFP. Analyses were performed by immunohistochemistry. RESULTS: Androgen-positive spindle cells were detected at the periphery of onion skin-like formations. Estrogen receptor-positive cells were not detected and Ki67 showed low proliferative activity. CONCLUSION: This case report shows for the first time the presence of androgen receptor-positive cells whose location corresponds with the distribution of Ki67-positive cells in IFP. Copyright
BACKGROUND/AIM: Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with inflammatory infiltrate. The aim of the present study was to investigate the presence of estrogen and androgen receptors in IFP and compare it with its proliferative loci. PATIENTS AND METHODS: The study analyzed a 79-year-old patient suffering from IFP. Analyses were performed by immunohistochemistry. RESULTS: Androgen-positive spindle cells were detected at the periphery of onion skin-like formations. Estrogen receptor-positive cells were not detected and Ki67 showed low proliferative activity. CONCLUSION: This case report shows for the first time the presence of androgen receptor-positive cells whose location corresponds with the distribution of Ki67-positive cells in IFP. Copyright
Authors: Faisal Inayat; Asad Ur Rahman; Ahsan Wahab; Amir Riaz; Effa Zahid; Pablo Bejarano; Ronnie Pimentel Journal: J Investig Med High Impact Case Rep Date: 2020 Jan-Dec