| Literature DB >> 25497741 |
W Pan1, A Q Zhang1, C L Yue1, J W Gao1, L Zeng1, W Gu1, J X Jiang1.
Abstract
Genetic association studies of the cytokine interleukin-10 (IL-10) and sepsis have provided inconsistent results. This work attempts to further quantitatively assess the association of three widely evaluated polymorphisms of IL-10 (-592C/A, -819C/T, -1082A/G) with sepsis susceptibility through a meta-analysis. A search of Pubmed, Web of Science and EMBASE databases was performed. Overall, the three polymorphisms have no strong association with sepsis risk. Subgroup analysis by ethnicity showed there was association between sepsis susceptibility with -592C/A in Caucasians (A vs. C: OR 0·78, 95% CI 0·62-1·00, P = 0·05; AA + CA vs. CC: OR 0·75, 95% CI 0·56-1·00, P = 0·05), and with -1082A/G in Asians (G vs. A: OR 1·41, 95% CI 1·04-1·91, P = 0·03; GG + AG vs. AA: OR 2·11, 95% CI 1·07-4·16, P = 0·03). This meta-analysis suggests that -592C/A and -1082A/G polymorphisms are associated with sepsis susceptibility in Caucasian, and Asian populations, respectively.Entities:
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Year: 2015 PMID： 25497741 PMCID： PMC9206783 DOI： 10.1017/S0950268814000703
Source DB: PubMed Journal: Epidemiol Infect ISSN： 0950-2688 Impact factor: 4.434