Paolo Castelnuovo1, Paolo Battaglia2, Mario Turri-Zanoni1, Giustino Tomei3, Davide Locatelli4, Maurizio Bignami1, Andrea Bolzoni Villaret5, Piero Nicolai5. 1. Department of Otorhinolaryngology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy. 2. Department of Otorhinolaryngology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy. Electronic address: mail.paolobattaglia@gmail.com. 3. Department of Neurosurgery, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy. 4. Department of Neurosurgery, Civic Hospital of Legnano, Legnano, Italy. 5. Department of Otorhinolaryngology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Abstract
OBJECTIVE: Data from several centers worldwide have demonstrated that transnasal endoscopic surgery performed with or without a transcranial approach is capable of achieving radical resection of selected sinonasal malignancies. We report our experience with endoscopic management of sinonasal cancers, with emphasis on naso-ethmoidal malignancies encroaching on the anterior skull base. METHODS: Major series reporting results concerning the endoscopic endonasal approach with or without craniectomy for treatment of sinonasal and anterior skull base cancers were reviewed. Preoperative work-up, indications and exclusion criteria, surgical techniques, postoperative management, and adjuvant therapy are reported. RESULTS: In the 2 largest series analyzed, the most common malignancies were adenocarcinoma (28%), olfactory neuroblastoma (14.5%), and squamous cell carcinoma (13.5%). The 5-year disease-specific survival rate ranged from 81.9%-87%, with no major differences in the mean follow-up time (34.1 months vs. 37 months). CONCLUSIONS: Endoscopic endonasal resection performed with or without a transcranial approach, when properly planned and in expert hands, has an accepted role with precise indications in the surgeon's armamentarium for the treatment of sinonasal and skull base malignancies.
OBJECTIVE: Data from several centers worldwide have demonstrated that transnasal endoscopic surgery performed with or without a transcranial approach is capable of achieving radical resection of selected sinonasal malignancies. We report our experience with endoscopic management of sinonasal cancers, with emphasis on naso-ethmoidal malignancies encroaching on the anterior skull base. METHODS: Major series reporting results concerning the endoscopic endonasal approach with or without craniectomy for treatment of sinonasal and anterior skull base cancers were reviewed. Preoperative work-up, indications and exclusion criteria, surgical techniques, postoperative management, and adjuvant therapy are reported. RESULTS: In the 2 largest series analyzed, the most common malignancies were adenocarcinoma (28%), olfactory neuroblastoma (14.5%), and squamous cell carcinoma (13.5%). The 5-year disease-specific survival rate ranged from 81.9%-87%, with no major differences in the mean follow-up time (34.1 months vs. 37 months). CONCLUSIONS: Endoscopic endonasal resection performed with or without a transcranial approach, when properly planned and in expert hands, has an accepted role with precise indications in the surgeon's armamentarium for the treatment of sinonasal and skull base malignancies.
Authors: Matthew R Naunheim; Neerav Goyal; Matthew M Dedmon; Kyle J Chambers; Ahmad R Sedaghat; Benjamin S Bleier; Eric H Holbrook; William T Curry; Stacey T Gray; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2016-03-18
Authors: Stefano Taboni; Marco Ferrari; Michael J Daly; Harley H L Chan; Donovan Eu; Tommaso Gualtieri; Ashok R Jethwa; Axel Sahovaler; Andrew Sewell; Wael Hasan; Ilyes Berania; Jimmy Qiu; John de Almeida; Piero Nicolai; Ralph W Gilbert; Jonathan C Irish Journal: Front Oncol Date: 2021-11-11 Impact factor: 6.244
Authors: P Battaglia; M Turri-Zanoni; F De Bernardi; P Dehgani Mobaraki; A Karligkiotis; F Leone; P Castelnuovo Journal: Acta Otorhinolaryngol Ital Date: 2016-06 Impact factor: 2.124