Literature DB >> 25496309

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors.

Matthieu Bertrand1, Valérie Petit, Ashish Jain, Raymonde Amsellem, Terje Johansen, Lionel Larue, Patrice Codogno, Isabelle Beau.   

Abstract

The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-derived epithelial cell lines. Modulation of the p62 level regulated the expression of junctional proteins. This effect was dependent on the ubiquitin-associated domain of p62, which stabilized the TGFβ/Smad signaling co-activator Smad4 and the EMT transcription factor Twist. This study highlights a novel function of p62 in a major epithelial phenotypic alteration.

Entities:  

Keywords:  EGF, epidermal growth factor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IGF-II, insulin growth factor II; MDCK, Madin Darby Canine Kidney; NMuMG, Normal Murine Mammary Gland; SQSTM1, Sequestosome 1; TGFβ, Transforming Growth Factor β; autophagy; smad proteins; snail; twist; ubiquitin

Mesh：

Substances：

Year:  2015        PMID： 25496309      PMCID： PMC4353226          DOI： 10.4161/15384101.2014.987619

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  24 in total

1.  Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail.

Authors:  Junichi Ikenouchi; Miho Matsuda; Mikio Furuse; Shoichiro Tsukita
Journal:  J Cell Sci       Date:  2003-03-26       Impact factor: 5.285

Review 2.  Selective autophagy mediated by autophagic adapter proteins.

Authors:  Terje Johansen; Trond Lamark
Journal:  Autophagy       Date:  2011-03       Impact factor: 16.016

Review 3.  Epithelial-mesenchymal transitions in development and disease.

Authors:  Jean Paul Thiery; Hervé Acloque; Ruby Y J Huang; M Angela Nieto
Journal:  Cell       Date:  2009-11-25       Impact factor: 41.582

4.  Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

Authors:  S Dennler; S Itoh; D Vivien; P ten Dijke; S Huet; J M Gauthier
Journal:  EMBO J       Date:  1998-06-01       Impact factor: 11.598

5.  Methods in mammalian autophagy research.

Authors:  Noboru Mizushima; Tamotsu Yoshimori; Beth Levine
Journal:  Cell       Date:  2010-02-05       Impact factor: 41.582

6.  Regulation of cell proliferation and migration by p62 through stabilization of Twist1.

Authors:  Lei Qiang; Baozhong Zhao; Mei Ming; Ning Wang; Tong-Chuan He; Seungmin Hwang; Andrew Thorburn; Yu-Ying He
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-09       Impact factor: 11.205

7.  Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

Authors:  Serhiy Pankiv; Trond Lamark; Jack-Ansgar Bruun; Aud Øvervatn; Geir Bjørkøy; Terje Johansen
Journal:  J Biol Chem       Date:  2009-12-15       Impact factor: 5.157

Review 8.  p62/SQSTM1/A170: physiology and pathology.

Authors:  Masaaki Komatsu; Shun Kageyama; Yoshinobu Ichimura
Journal:  Pharmacol Res       Date:  2012-07-25       Impact factor: 7.658

9.  p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Authors:  Serhiy Pankiv; Terje Høyvarde Clausen; Trond Lamark; Andreas Brech; Jack-Ansgar Bruun; Heidi Outzen; Aud Øvervatn; Geir Bjørkøy; Terje Johansen
Journal:  J Biol Chem       Date:  2007-06-19       Impact factor: 5.157

10.  Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.

Authors:  Samy Lamouille; Rik Derynck
Journal:  J Cell Biol       Date:  2007-07-23       Impact factor: 10.539
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  33 in total

1.  TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.

Authors:  Chen Liang; Jin Xu; Qingcai Meng; Bo Zhang; Jiang Liu; Jie Hua; Yiyin Zhang; Si Shi; Xianjun Yu
Journal:  Autophagy       Date:  2019-06-17       Impact factor: 16.016

Review 2.  Autophagy and Hallmarks of Cancer.

Authors:  Tianzhi Huang; Xiao Song; Yongyong Yang; Xuechao Wan; Angel A Alvarez; Namratha Sastry; Haizhong Feng; Bo Hu; Shi-Yuan Cheng
Journal:  Crit Rev Oncog       Date:  2018

3.  Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.

Authors:  Ann F Hubbs; Kara L Fluharty; Rebekah J Edwards; Jamie L Barnabei; John T Grantham; Scott M Palmer; Francine Kelly; Linda M Sargent; Steven H Reynolds; Robert R Mercer; Madhusudan P Goravanahally; Michael L Kashon; John C Honaker; Mark C Jackson; Amy M Cumpston; William T Goldsmith; Walter McKinney; Jeffrey S Fedan; Lori A Battelli; Tiffany Munro; Winnie Bucklew-Moyers; Kimberly McKinstry; Diane Schwegler-Berry; Sherri Friend; Alycia K Knepp; Samantha L Smith; Krishnan Sriram
Journal:  Am J Pathol       Date:  2016-11       Impact factor: 4.307

Review 4.  Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment.

Authors:  Lihui Si; Zecheng Yang; Lu Ding; Duoduo Zhang
Journal:  J Cancer Res Clin Oncol       Date:  2022-01-27       Impact factor: 4.553

5.  The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells.

Authors:  Ozge Alvur; Hakan Kucuksayan; Yasemin Baygu; Nilgun Kabay; Yasar Gok; Hakan Akca
Journal:  Mol Biol Rep       Date:  2021-11-13       Impact factor: 2.316

Review 6.  Mechanisms and context underlying the role of autophagy in cancer metastasis.

Authors:  Christopher M Dower; Carson A Wills; Steven M Frisch; Hong-Gang Wang
Journal:  Autophagy       Date:  2018-06-04       Impact factor: 16.016

7.  Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.

Authors:  Tania M Puvirajesinghe; François Bertucci; Ashish Jain; Pierluigi Scerbo; Edwige Belotti; Stéphane Audebert; Michael Sebbagh; Marc Lopez; Andreas Brech; Pascal Finetti; Emmanuelle Charafe-Jauffret; Max Chaffanet; Rémy Castellano; Audrey Restouin; Sylvie Marchetto; Yves Collette; Anthony Gonçalvès; Ian Macara; Daniel Birnbaum; Laurent Kodjabachian; Terje Johansen; Jean-Paul Borg
Journal:  Nat Commun       Date:  2016-01-12       Impact factor: 14.919

8.  Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.

Authors:  G Grassi; G Di Caprio; L Santangelo; G M Fimia; A M Cozzolino; M Komatsu; G Ippolito; M Tripodi; T Alonzi
Journal:  Cell Death Dis       Date:  2015-09-10       Impact factor: 8.469

9.  Autophagy positively regulates DNA damage recognition by nucleotide excision repair.

Authors:  Lei Qiang; Baozhong Zhao; Palak Shah; Ashley Sample; Seungwon Yang; Yu-Ying He
Journal:  Autophagy       Date:  2015-11-13       Impact factor: 16.016

10.  Defective autophagy is a key feature of cerebral cavernous malformations.

Authors:  Saverio Marchi; Mariangela Corricelli; Eliana Trapani; Luca Bravi; Alessandra Pittaro; Simona Delle Monache; Letizia Ferroni; Simone Patergnani; Sonia Missiroli; Luca Goitre; Lorenza Trabalzini; Alessandro Rimessi; Carlotta Giorgi; Barbara Zavan; Paola Cassoni; Elisabetta Dejana; Saverio Francesco Retta; Paolo Pinton
Journal:  EMBO Mol Med       Date:  2015-11       Impact factor: 12.137
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