Literature DB >> 25492945

Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.

Juan L Pablo1, Geoffrey S Pitt2.   

Abstract

Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na(+) channels (NaVs). In this review, we discuss new insights into how FHFs modulate NaVs. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.
© The Author(s) 2014.

Entities:  

Keywords:  fibroblast growth factor homologous factors; fibroblast growth factors; neuron cell biology; spinocerebellar ataxia; voltage-gated sodium channels

Mesh：

Substances：

Year:  2014        PMID： 25492945      PMCID： PMC4555190          DOI： 10.1177/1073858414562217

Source DB:  PubMed          Journal:  Neuroscientist        ISSN： 1073-8584            Impact factor:   7.519


  46 in total

1.  Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier.

Authors:  M R Kaplan; M H Cho; E M Ullian; L L Isom; S R Levinson; B A Barres
Journal:  Neuron       Date:  2001-04       Impact factor: 17.173

2.  Fibroblast growth factor homologous factor 1B binds to the C terminus of the tetrodotoxin-resistant sodium channel rNav1.9a (NaN).

Authors:  S D Dib-Hajj; S G Waxman
Journal:  J Biol Chem       Date:  2001-03-16       Impact factor: 5.157

Review 3.  Determinants of voltage-gated sodium channel clustering in neurons.

Authors:  Christophe Leterrier; Anna Brachet; Bénédicte Dargent; Helene Vacher
Journal:  Semin Cell Dev Biol       Date:  2010-10-08       Impact factor: 7.727

4.  A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar ataxia [corrected].

Authors:  John C van Swieten; Esther Brusse; Bianca M de Graaf; Elmar Krieger; Raoul van de Graaf; Inge de Koning; Anneke Maat-Kievit; Peter Leegwater; Dennis Dooijes; Ben A Oostra; Peter Heutink
Journal:  Am J Hum Genet       Date:  2002-12-13       Impact factor: 11.025

5.  Long-term inactivation particle for voltage-gated sodium channels.

Authors:  Katarzyna Dover; Sergio Solinas; Egidio D'Angelo; Mitchell Goldfarb
Journal:  J Physiol       Date:  2010-08-02       Impact factor: 5.182

6.  Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing.

Authors:  I Munoz-Sanjuan; P M Smallwood; J Nathans
Journal:  J Biol Chem       Date:  2000-01-28       Impact factor: 5.157

7.  Fibroblast growth factor homologous factors are intracellular signaling proteins.

Authors:  J Schoorlemmer; M Goldfarb
Journal:  Curr Biol       Date:  2001-05-15       Impact factor: 10.834

8.  Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding.

Authors:  Mingxuan Xu; Yuanzheng Gu; Joshua Barry; Chen Gu
Journal:  J Neurosci       Date:  2010-11-24       Impact factor: 6.167

9.  Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14.

Authors:  Qing Wang; Mark E Bardgett; Michael Wong; David F Wozniak; Junyang Lou; Benjamin D McNeil; Chen Chen; Anthony Nardi; David C Reid; Kelvin Yamada; David M Ornitz
Journal:  Neuron       Date:  2002-07-03       Impact factor: 17.173

10.  Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.

Authors:  Jon Schoorlemmer; Mitchell Goldfarb
Journal:  J Biol Chem       Date:  2002-09-18       Impact factor: 5.157
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  18 in total

Review 1.  Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death.

Authors:  Hugues Abriel; Jean-Sébastien Rougier; José Jalife
Journal:  Circ Res       Date:  2015-06-05       Impact factor: 17.367

2.  Divide, multitask, and conquer: Coordination in channel regulation.

Authors:  Juan Lorenzo Pablo; Geoffrey S Pitt
Journal:  Channels (Austin)       Date:  2017-03-02       Impact factor: 2.581

3.  Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.

Authors:  Jacqueline Niu; Ivy E Dick; Wanjun Yang; Moradeke A Bamgboye; David T Yue; Gordon Tomaselli; Takanari Inoue; Manu Ben-Johny
Journal:  Elife       Date:  2018-09-10       Impact factor: 8.140

4.  Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.

Authors:  Juan Lorenzo Pablo; Chaojian Wang; Matthew M Presby; Geoffrey S Pitt
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-04       Impact factor: 11.205

5.  Another piece to the intracellular FGF/Na+ channel puzzle.

Authors:  Elizabeth J Akin; Michael M Tamkun
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-26       Impact factor: 11.205

6.  iFGF14-Navs: A monogamous partnership?

Authors:  Sulayman D Dib-Hajj
Journal:  Channels (Austin)       Date:  2016-06-28       Impact factor: 2.581

7.  FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons.

Authors:  Cindy Barbosa; Yucheng Xiao; Andrew J Johnson; Wenrui Xie; Judith A Strong; Jun-Ming Zhang; Theodore R Cummins
Journal:  Pflugers Arch       Date:  2016-12-20       Impact factor: 3.657

8.  Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27.

Authors:  Filippo Tempia; Eriola Hoxha; Giulia Negro; Musaad A Alshammari; Tahani K Alshammari; Neli Panova-Elektronova; Fernanda Laezza
Journal:  Front Cell Neurosci       Date:  2015-06-04       Impact factor: 5.505

9.  De Novo FGF12 (Fibroblast Growth Factor 12) Functional Variation Is Potentially Associated With Idiopathic Ventricular Tachycardia.

Authors:  Qianqian Li; Yuanyuan Zhao; Gang Wu; Shanshan Chen; Yingchao Zhou; Sisi Li; Mengchen Zhou; Qian Fan; Jielin Pu; Kui Hong; Xiang Cheng; Qing Kenneth Wang; Xin Tu
Journal:  J Am Heart Assoc       Date:  2017-08-03       Impact factor: 5.501

10.  Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.

Authors:  Scott A Alpizar; Arielle L Baker; Allan T Gulledge; Michael B Hoppa
Journal:  Front Cell Neurosci       Date:  2019-01-22       Impact factor: 5.505
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