Literature DB >> 25492534

Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer.

Huiying Wang1, Yingnan Wang1, Qun Zhao2, Zhanjun Guo1, Fengbin Zhang1, Yue Zhao1, Ruixing Zhang1.   

Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.

Entities:  

Keywords:  D-Loop; SNPs; gastric cancer; mtDNA

Mesh：

Substances：

Year:  2015        PMID： 25492534     DOI： 10.3109/19401736.2014.926546

Source DB:  PubMed          Journal:  Mitochondrial DNA A DNA Mapp Seq Anal        ISSN： 2470-1394            Impact factor:   1.514


  6 in total

1.  Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for gastroenteropancreatic neuroendocrine neoplasm.

Authors:  Li-Mian Er; Ming-Li Wu; Yang Gao; Shi-Jie Wang; Yong Li
Journal:  J Clin Lab Anal       Date:  2016-10-05       Impact factor: 2.352

2.  Identification of sequence polymorphisms in the mitochondrial deoxyribonucleic acid displacement-loop region as risk factors for systemic lupus erythematosus.

Authors:  Ruixue Lai; Xiaoyun Zhang; Kuangyuan Qiao; Xueqing Gao; Shang Li; Ruixing Zhang; Yixin Qi; Chenxing Peng
Journal:  Arch Rheumatol       Date:  2020-12-14       Impact factor: 1.472

3.  Mitochondria in tumour progression: a network of mtDNA variants in different types of cancer.

Authors:  Giovanna C Cavalcante; Ândrea Ribeiro-Dos-Santos; Gilderlanio S de Araújo
Journal:  BMC Genom Data       Date:  2022-02-18

4.  The SNPs of mitochondrial DNA displacement loop region and mitochondrial DNA copy number associated with risk of polymyositis and dermatomyositis.

Authors:  Yufei Zhao; Chenxing Peng; Ruixue Lai; Jingjing Zhang; Xiaoyun Zhang; Zhanjun Guo
Journal:  Sci Rep       Date:  2022-04-07       Impact factor: 4.379

5.  Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer.

Authors:  Cuiju Wang; Yingnan Wang; Huiying Wang; Ruixing Zhang; Zhanjun Guo
Journal:  Tumour Biol       Date:  2014-09-09

6.  Identification of polymorphisms in mitochondrial cytochrome c oxidase genes as risk factors for gastric cancer.

Authors:  Yingnan Wang; Hongcai Wang; Shice Yin; Jingjing Zhang; Ruixing Zhang; Zhanjun Guo
Journal:  Transl Cancer Res       Date:  2020-06       Impact factor: 1.241
  6 in total

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