Literature DB >> 25492359

New potential for enhancing concomitant chemoradiotherapy with FDA approved concentrations of cisplatin via the photoelectric effect.

Yucel Altundal1, Gizem Cifter2, Alexandre Detappe3, Erno Sajo2, Panagiotis Tsiamas4, Piotr Zygmanski4, Ross Berbeco4, Robert A Cormack4, Mike Makrigiorgos4, Wilfred Ngwa5.   

Abstract

We predict, for the first time, that by using United States Food and Drug Administration approved concentrations of cisplatin, major radiosensitization may be achieved via photoelectric mechanism during concomitant chemoradiotherapy (CCRT). Our analytical calculations estimate that radiotherapy (RT) dose to cancer cells may be enhanced via this mechanism by over 100% during CCRT. The results proffer new potential for significantly enhancing CCRT via an emerging clinical scenario, where the cisplatin is released in-situ from RT biomaterials loaded with cisplatin nanoparticles.
Copyright © 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Brachytherapy; Chemoradiotherapy; Cisplatin nanoparticles; Dose enhancement; Radiotherapy

Mesh：

Substances：

Year:  2014        PMID： 25492359      PMCID： PMC4492437          DOI： 10.1016/j.ejmp.2014.11.004

Source DB:  PubMed          Journal:  Phys Med        ISSN： 1120-1797            Impact factor:   2.685


  42 in total

1.  Localized dose enhancement to tumor blood vessel endothelial cells via megavoltage X-rays and targeted gold nanoparticles: new potential for external beam radiotherapy.

Authors:  Ross I Berbeco; Wilfred Ngwa; G Mike Makrigiorgos
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-12-14       Impact factor: 7.038

2.  Preparation and characterization of magnetic gold nanoparticles to be used as doxorubicin nanocarriers.

Authors:  Nihal Saad Elbialy; Mohammed Mahmoud Fathy; Wafaa Mohamed Khalil
Journal:  Phys Med       Date:  2014-06-18       Impact factor: 2.685

3.  The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles.

Authors:  Alexandre Detappe; Panagiotis Tsiamas; Wilfred Ngwa; Piotr Zygmanski; Mike Makrigiorgos; Ross Berbeco
Journal:  Med Phys       Date:  2013-03       Impact factor: 4.071

4.  Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.

Authors:  Poulomi Sengupta; Sudipta Basu; Shivani Soni; Ambarish Pandey; Bhaskar Roy; Michael S Oh; Kenneth T Chin; Abhimanyu S Paraskar; Sasmit Sarangi; Yamicia Connor; Venkata S Sabbisetti; Jawahar Kopparam; Ashish Kulkarni; Katherine Muto; Chitra Amarasiriwardena; Innocent Jayawardene; Nicola Lupoli; Daniela M Dinulescu; Joseph V Bonventre; Raghunath A Mashelkar; Shiladitya Sengupta
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

5.  Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles.

Authors:  Xiang-Hong Peng; Yiqing Wang; Donghai Huang; Yuxiang Wang; Hyung Juc Shin; Zhengjia Chen; Michael B Spewak; Hui Mao; Xu Wang; Ying Wang; Zhuo Georgia Chen; Shuming Nie; Dong M Shin
Journal:  ACS Nano       Date:  2011-11-04       Impact factor: 15.881

6.  Biophysical characterization of gold nanoparticles-loaded liposomes.

Authors:  Mohsen Mahmoud Mady; Mohamed Mahmoud Fathy; Tareq Youssef; Wafaa Mohamed Khalil
Journal:  Phys Med       Date:  2011-10-24       Impact factor: 2.685

7.  Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation.

Authors:  Zhongli Cai; Jean-Philippe Pignol; Niladri Chattopadhyay; Yongkyu Luke Kwon; Eli Lechtman; Raymond M Reilly
Journal:  Med Phys       Date:  2013-11       Impact factor: 4.071

8.  Efficacy of intracerebral delivery of cisplatin in combination with photon irradiation for treatment of brain tumors.

Authors:  Julia Rousseau; Rolf F Barth; Manuel Fernandez; Jean-François Adam; Jacques Balosso; François Estève; Hélène Elleaume
Journal:  J Neurooncol       Date:  2009-12-11       Impact factor: 4.130

9.  The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.

Authors:  Joseph J Sacco; Joanne Botten; Fergus Macbeth; Adrian Bagust; Peter Clark
Journal:  PLoS One       Date:  2010-01-28       Impact factor: 3.240

10.  Cisplatin tumor biodistribution and efficacy after intratumoral injection of a biodegradable extended release implant.

Authors:  Ariella Shikanov; Sergey Shikanov; Boris Vaisman; Jacob Golenser; Abraham J Domb
Journal:  Chemother Res Pract       Date:  2011-02-27
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  9 in total

1.  Potential of using cerium oxide nanoparticles for protecting healthy tissue during accelerated partial breast irradiation (APBI).

Authors:  Zi Ouyang; Madan Kumar Mainali; Neeharika Sinha; Guinevere Strack; Yucel Altundal; Yao Hao; Thomas Andrew Winningham; Erno Sajo; Jonathan Celli; Wilfred Ngwa
Journal:  Phys Med       Date:  2016-04-01       Impact factor: 2.685

2.  Nanoparticle-aided Radiotherapy for Retinoblastoma and Choroidal Melanoma.

Authors:  Yucel Altundal; Erno Sajo; G Mike Makrigiorgos; Ross I Berbeco; Wilfred Ngwa
Journal:  IFMBE Proc       Date:  2015

Review 3.  Smart Radiation Therapy Biomaterials.

Authors:  Wilfred Ngwa; Francis Boateng; Rajiv Kumar; Darrell J Irvine; Silvia Formenti; Twalib Ngoma; Carsten Herskind; Marlon R Veldwijk; Georg Lars Hildenbrand; Michael Hausmann; Frederik Wenz; Juergen Hesser
Journal:  Int J Radiat Oncol Biol Phys       Date:  2016-11-01       Impact factor: 7.038

4.  Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams.

Authors:  Noor Nabilah Talik Sisin; Khairunisak Abdul Razak; Safri Zainal Abidin; Nor Fazila Che Mat; Reduan Abdullah; Raizulnasuha Ab Rashid; Muhammad Afiq Khairil Anuar; Wan Nordiana Rahman
Journal:  Int J Nanomedicine       Date:  2020-10-12

5.  A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles.

Authors:  M Jermoumi; A Yucel; Y Hao; G Cifter; E Sajo; W Ngwa
Journal:  IFMBE Proc       Date:  2015-06

6.  Potential for enhancing external beam radiotherapy for lung cancer using high-Z nanoparticles administered via inhalation.

Authors:  Yao Hao; Yucel Altundal; Michele Moreau; Erno Sajo; Rajiv Kumar; Wilfred Ngwa
Journal:  Phys Med Biol       Date:  2015-08-26       Impact factor: 3.609

7.  Novel bioerodable eluting-spacers for radiotherapy applications with in situ dose painting.

Authors:  Francis Boateng; Wilfred Ngwa
Journal:  Br J Radiol       Date:  2019-05-14       Impact factor: 3.039

8.  Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids.

Authors:  Wilfred Ngwa; Rajiv Kumar; Michele Moreau; Raymond Dabney; Allen Herman
Journal:  Front Oncol       Date:  2017-09-19       Impact factor: 6.244

Review 9.  Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications.

Authors:  Francis Boateng; Wilfred Ngwa
Journal:  Int J Mol Sci       Date:  2019-12-31       Impact factor: 5.923
  9 in total

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