OBJECTIVES/HYPOTHESIS: To determine risk factors for decannulation failure after laryngotracheal reconstruction performed at a single institution over a 10-year period. STUDY DESIGN: This is a retrospective cohort study. METHODS: The study population included 95 adult patients who underwent laryngotracheal reconstruction at a single tertiary care medical center between 2003 and 2012. Data were retrospectively reviewed. RESULTS: Our cohort consisted of 95 subjects (60% female) with a median (range) age of 48 (21-82) years. Fourteen patients failed to decannulate by one postoperative year and were more likely to have diabetes, gastroesophageal reflux disease, grade 4 stenosis, T-tube requirement, secondary tracheotomy, double-stage reconstruction, and more endoscopic dilations within the first postoperative year. T-tube requirement was highly predictive of decannulation failure, with an odds ratio of 50.6 in univariate analysis and 93.7 in multivariate analysis. Grade 4 stenosis and a requirement of at least one postoperative endoscopic dilation were also found significant under both univariate and multivariate models. Gastroesophageal reflux disease was marginally significant under the univariate and multivariate models (P = .059 and .088, respectively). CONCLUSIONS: The presence of preoperative and postoperative factors may indicate a higher risk of decannulation failure after laryngotracheal reconstruction. Patients with diabetes, gastroesophageal reflux disease, and grade 4 stenosis are at higher risk for decannulation failure. Requirement of T-tube placement and requirement of endoscopic dilation are predictive of decannulation failure.
OBJECTIVES/HYPOTHESIS: To determine risk factors for decannulation failure after laryngotracheal reconstruction performed at a single institution over a 10-year period. STUDY DESIGN: This is a retrospective cohort study. METHODS: The study population included 95 adult patients who underwent laryngotracheal reconstruction at a single tertiary care medical center between 2003 and 2012. Data were retrospectively reviewed. RESULTS: Our cohort consisted of 95 subjects (60% female) with a median (range) age of 48 (21-82) years. Fourteen patients failed to decannulate by one postoperative year and were more likely to have diabetes, gastroesophageal reflux disease, grade 4 stenosis, T-tube requirement, secondary tracheotomy, double-stage reconstruction, and more endoscopic dilations within the first postoperative year. T-tube requirement was highly predictive of decannulation failure, with an odds ratio of 50.6 in univariate analysis and 93.7 in multivariate analysis. Grade 4 stenosis and a requirement of at least one postoperative endoscopic dilation were also found significant under both univariate and multivariate models. Gastroesophageal reflux disease was marginally significant under the univariate and multivariate models (P = .059 and .088, respectively). CONCLUSIONS: The presence of preoperative and postoperative factors may indicate a higher risk of decannulation failure after laryngotracheal reconstruction. Patients with diabetes, gastroesophageal reflux disease, and grade 4 stenosis are at higher risk for decannulation failure. Requirement of T-tube placement and requirement of endoscopic dilation are predictive of decannulation failure.
Authors: Deborah X Xie; Saad C Rehman; David O Francis; James L Netterville; C Gaelyn Garrett; Alexander Gelbard; Brittany Lipscomb; Christopher T Wootten Journal: JAMA Otolaryngol Head Neck Surg Date: 2019-03-01 Impact factor: 6.223
Authors: Ioan Lina; Hsiu-Wen Tsai; Dacheng Ding; Ruth Davis; Kevin M Motz; Alexander T Hillel Journal: Laryngoscope Date: 2020-08-28 Impact factor: 2.970
Authors: Paulo Francisco Guerreiro Cardoso; Helio Minamoto; Benoit Jacques Bibas; Paulo Manuel Pego-Fernandes Journal: Transl Cancer Res Date: 2020-03 Impact factor: 1.241