Literature DB >> 25489583

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations.

Guislaine Barriere1, Pietro Fici1, Giulia Gallerani1, Francesco Fabbri1, Wainer Zoli1, Michel Rigaud1.   

Abstract

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.

Entities:  

Keywords:  Circulating tumor cells (CTCs); epithelial mesenchymal transition (EMT); stemness

Year:  2014        PMID： 25489583      PMCID： PMC4245517          DOI： 10.3978/j.issn.2305-5839.2014.10.04

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  49 in total

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  53 in total

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