Literature DB >> 25489569

An unusual presentation of childhood vasculitis presenting in adulthood: a challenging diagnosis of henoch-schönlein purpura.

Charat Thongprayoon1, Wisit Cheungpasitporn2, Natanong Thamcharoen3, Jackrapong Bruminhent1.   

Abstract

CONTEXT: Henoch-Schönlein purpura (HSP), a systemic IgA vascultitis, is uncommon in adults, with an incidence rate of 0.1 to 1.2 per million in adults over 20 years old. This vasculitic syndrome can present as an uncommon cause of intestinal obstruction in older patients. We report a case of an older woman with HSP presenting with small bowel obstruction and vasculitic rash. CASE REPORT: We report a 67-year-old woman who presented with small bowel obstruction and skin rash. Skin biopsy revealed leukocytoclastic vasculitis with +IgA granular deposition within the walls of superficial dermal vessels. Kidney biopsy confirmed the diagnosis of HSP with mild mesangial proliferative IgA nephropathy. Her abdominal pain and small bowel obstruction were improved with conservative treatment. She continued to do well with normal kidney function at a 3-month follow-up visit.
CONCLUSION: HSP, a systemic IgA vasculitis, is a predominantly pediatric vasculitis and is uncommon in adults. In adults, the disease process is identical to that in children. However, gastrointestinal manifestation is less common in older patients, and bowel perforation and obstruction are rare. Intestinal obstruction with skin rash and renal involvement should raise suspicions of HSP.

Entities:  

Keywords:  Henoch-Schönlein purpura; Intestinal obstruction; Vasculitis

Year:  2014        PMID: 25489569      PMCID: PMC4215494          DOI: 10.4103/1947-2714.143289

Source DB:  PubMed          Journal:  N Am J Med Sci        ISSN: 1947-2714


  7 in total

1.  Henoch-Schönlein purpura in an older man presenting as rectal bleeding and IgA mesangioproliferative glomerulonephritis: a case report.

Authors:  Wisit Cheungpasitporn; Teeranun Jirajariyavej; Charles B Howarth; Raquel M Rosen
Journal:  J Med Case Rep       Date:  2011-08-10

Review 2.  Aging promotes progression of IgA nephropathy: a systematic review and meta-analysis.

Authors:  Zhi-Yu Duan; Guang-Yan Cai; Yi-Zhi Chen; Shuang Liang; Shu-Wen Liu; Jie Wu; Qiang Qiu; Shu-Peng Lin; Xue-Guang Zhang; Xiang-Mei Chen
Journal:  Am J Nephrol       Date:  2013-09-10       Impact factor: 3.754

Review 3.  IgA nephropathy.

Authors:  Jonathan Barratt; John Feehally
Journal:  J Am Soc Nephrol       Date:  2005-06-01       Impact factor: 10.121

4.  Radiologic findings of gastrointestinal complications in an adult patient with Henoch-Schönlein purpura.

Authors:  Dong Jin Chung; Yong Sung Park; Kyu Chan Huh; Ji Hyung Kim
Journal:  AJR Am J Roentgenol       Date:  2006-10       Impact factor: 3.959

Review 5.  IgA nephropathy.

Authors:  Robert J Wyatt; Bruce A Julian
Journal:  N Engl J Med       Date:  2013-06-20       Impact factor: 91.245

Review 6.  The commonest glomerulonephritis in the world: IgA nephropathy.

Authors:  G D'Amico
Journal:  Q J Med       Date:  1987-09

7.  Epidemiology of systemic vasculitis: changing incidence or definition?

Authors:  R A Watts; D M Carruthers; D G Scott
Journal:  Semin Arthritis Rheum       Date:  1995-08       Impact factor: 5.532

  7 in total

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