BACKGROUND: There has been considerable interest in whether old age is associated with IgA nephropathy (IgAN) progression, which is still controversial. METHODS: We searched multiple databases for studies published from 1980 to 2012. The inclusion criteria were case-control, cohort studies published in any language. The included studies needed to have an older group. IgAN was proven by biopsy. RESULTS: We included 9 studies with a total of 6,543 patients. The meta-analyses of other risk factors between the older group (>50 years old) and the non-older group (15-50 years old) found significant differences in the presence of hypertension, proteinuria, serum cholesterol levels and baseline renal function. In the overall analysis, compared to the non-older group, older age significantly increased the incidence of developing end-stage renal disease [ESRD; relative risk (RR) random model 1.95; 95% CI: 1.27-3.01]. In the subgroup analyses, we found the age limit and traditional risk factors of IgAN may be the sources of heterogeneity between studies. Moreover, the RR (2.56) of the Asian countries was much higher than the RR (1.11) of the European countries. CONCLUSIONS: This comprehensive review revealed that old age is a real risk factor for IgAN progression to ESRD. The incidence of ESRD in the older IgAN patients was 1.95 times higher than that in the non-older IgAN patients. Moreover, the risk of IgAN progression to ESRD of the older patients in Asia was higher than that of the older patients in Europe.
BACKGROUND: There has been considerable interest in whether old age is associated with IgA nephropathy (IgAN) progression, which is still controversial. METHODS: We searched multiple databases for studies published from 1980 to 2012. The inclusion criteria were case-control, cohort studies published in any language. The included studies needed to have an older group. IgAN was proven by biopsy. RESULTS: We included 9 studies with a total of 6,543 patients. The meta-analyses of other risk factors between the older group (>50 years old) and the non-older group (15-50 years old) found significant differences in the presence of hypertension, proteinuria, serum cholesterol levels and baseline renal function. In the overall analysis, compared to the non-older group, older age significantly increased the incidence of developing end-stage renal disease [ESRD; relative risk (RR) random model 1.95; 95% CI: 1.27-3.01]. In the subgroup analyses, we found the age limit and traditional risk factors of IgAN may be the sources of heterogeneity between studies. Moreover, the RR (2.56) of the Asian countries was much higher than the RR (1.11) of the European countries. CONCLUSIONS: This comprehensive review revealed that old age is a real risk factor for IgAN progression to ESRD. The incidence of ESRD in the older IgANpatients was 1.95 times higher than that in the non-older IgANpatients. Moreover, the risk of IgAN progression to ESRD of the older patients in Asia was higher than that of the older patients in Europe.
Authors: Angel M Sevillano; Monserrat Diaz; Fernando Caravaca-Fontán; Clara Barrios; Carmen Bernis; Jimena Cabrera; Jesus Calviño; Lorena Castillo; Carmen Cobelo; Patricia Delgado-Mallén; Mario Espinosa; Gema Fernandez-Juarez; Maria Jose Fernandez-Reyes; Rosa Garcia-Osuna; Patricia Garcia; Marian Goicoechea; Fayna Gonzalez-Cabrera; Diomaris A Guzmán; Manuel Heras; Guillermo Martín-Reyes; Alberto Martinez; Teresa Olea; Jessy Korina Peña; Luis F Quintana; Cristina Rabasco; Katia López Revuelta; Lida Rodas; Nuria Rodriguez-Mendiola; Eva Rodriguez; Luz San Miguel; Maria Dolores Sanchez de la Nieta; Amir Shabaka; Milagros Sierra; Alfonso Valera; Mercedes Velo; Eduardo Verde; Jose Ballarin; Oscar Noboa; Juan Antonio Moreno; Eduardo Gutiérrez; Manuel Praga Journal: Clin J Am Soc Nephrol Date: 2019-07-16 Impact factor: 8.237
Authors: Won Jung Choi; Yu A Hong; Ji Won Min; Eun Sil Koh; Hyung Duk Kim; Tae Hyun Ban; Young Soo Kim; Yong Kyun Kim; Seok Joon Shin; Seok Young Kim; Young Ok Kim; Chul Woo Yang; Yoon-Kyung Chang Journal: J Clin Med Date: 2021-04-27 Impact factor: 4.241
Authors: Inonge van Twillert; Axel A Bonačić Marinović; Betsy Kuipers; Jacqueline A M van Gaans-van den Brink; Elisabeth A M Sanders; Cécile A C M van Els Journal: Sci Rep Date: 2017-01-16 Impact factor: 4.379