Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.

Literature DB >> 25489490

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.

Catherine Baugé¹, Nicolas Girard¹, Eva Lhuissier¹, Celine Bazille², Karim Boumediene¹.

Abstract

Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.

Entities: Disease Gene

Keywords: TGFbeta; aging; chondrocytes; osteoarthritis

Year: 2013 PMID： 25489490 PMCID： PMC4249809 DOI： 10.14336/AD.2014.0500394

Source DB: PubMed Journal: Aging Dis ISSN： 2152-5250 Impact factor: 6.745

147 in total

1. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.

Authors: M E Engel; M A McDonnell; B K Law; H L Moses
Journal: J Biol Chem Date: 1999-12-24 Impact factor: 5.157

2. Porous gelatin-chondroitin-hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-beta1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair.

Authors: Hongbin Fan; Yunyu Hu; Ling Qin; Xusheng Li; Hong Wu; Rong Lv
Journal: J Biomed Mater Res A Date: 2006-06-15 Impact factor: 4.396

3. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis.

Authors: A C Gelber; M C Hochberg; L A Mead; N Y Wang; F M Wigley; M J Klag
Journal: Ann Intern Med Date: 2000-09-05 Impact factor: 25.391

Review 4. Why is osteoarthritis an age-related disease?

Authors: A Shane Anderson; Richard F Loeser
Journal: Best Pract Res Clin Rheumatol Date: 2010-02 Impact factor: 4.098

5. ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.

Authors: Kenneth W Finnson; Wendy L Parker; Peter ten Dijke; Midory Thorikay; Anie Philip
Journal: J Bone Miner Res Date: 2008-06 Impact factor: 6.741

6. Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Authors: Jie Shen; Jia Li; Baoli Wang; Hongting Jin; Meina Wang; Yejia Zhang; Yunzhi Yang; Hee-Jeong Im; Regis O'Keefe; Di Chen
Journal: Arthritis Rheum Date: 2013-12

7. Transforming growth factor-beta 1 (TGF-beta 1) up-regulation of collagen type II in primary cultures of rabbit articular chondrocytes (RAC) involves increased mRNA levels without affecting mRNA stability and procollagen processing.

Authors: P Galéra; D Vivien; S Pronost; J Bonaventure; F Rédini; G Loyau; J P Pujol
Journal: J Cell Physiol Date: 1992-12 Impact factor: 6.384

8. Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.

Authors: R B A Vaes; F Rivadeneira; J M Kerkhof; A Hofman; H A P Pols; A G Uitterlinden; J B J van Meurs
Journal: Ann Rheum Dis Date: 2008-11-24 Impact factor: 19.103

9. Novel gene-modified-tissue engineering of cartilage using stable transforming growth factor-beta1-transfected mesenchymal stem cells grown on chitosan scaffolds.

Authors: Chang-An Guo; Xue-Guang Liu; Jian-Zhong Huo; Chun Jiang; Xue-Jun Wen; Zheng-Rong Chen
Journal: J Biosci Bioeng Date: 2007-06 Impact factor: 2.894

10. TGF-ß1 enhances the BMP-2-induced chondrogenesis of bovine synovial explants and arrests downstream differentiation at an early stage of hypertrophy.

Authors: Nahoko Shintani; Klaus A Siebenrock; Ernst B Hunziker
Journal: PLoS One Date: 2013-01-03 Impact factor: 3.240

28 in total

Review 1. TGFβ/BMP Signaling Pathway in Cartilage Homeostasis.

Authors: Nathalie G M Thielen; Peter M van der Kraan; Arjan P M van Caam
Journal: Cells Date: 2019-08-24 Impact factor: 6.600

Review 2. Rhythm disturbance in osteoarthritis.

Authors: Ze Du; Xuanhe You; Diwei Wu; Shishu Huang; Zongke Zhou
Journal: Cell Commun Signal Date: 2022-05-24 Impact factor: 7.525

Review 3. Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights.

Authors: Li Lei; Li Meng; Xu Changqing; Zhu Chen; Yao Gang; Fang Shiyuan
Journal: Open Life Sci Date: 2022-07-07 Impact factor: 1.311

4. The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.

Authors: Michal Dudek; Nicole Gossan; Nan Yang; Hee-Jeong Im; Jayalath P D Ruckshanthi; Hikari Yoshitane; Xin Li; Ding Jin; Ping Wang; Maya Boudiffa; Ilaria Bellantuono; Yoshitaka Fukada; Ray P Boot-Handford; Qing-Jun Meng
Journal: J Clin Invest Date: 2015-12-14 Impact factor: 14.808

5. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk.

Authors: Daniel Richard; Zun Liu; Jiaxue Cao; Ata M Kiapour; Jessica Willen; Siddharth Yarlagadda; Evelyn Jagoda; Vijaya B Kolachalama; Jakob T Sieker; Gary H Chang; Pushpanathan Muthuirulan; Mariel Young; Anand Masson; Johannes Konrad; Shayan Hosseinzadeh; David E Maridas; Vicki Rosen; Roman Krawetz; Neil Roach; Terence D Capellini
Journal: Cell Date: 2020-03-26 Impact factor: 41.582

6. Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.

Authors: Nobuaki Chinzei; Muhammad Farooq Rai; Shingo Hashimoto; Eric J Schmidt; Ken Takebe; James M Cheverud; Linda J Sandell
Journal: Arthritis Rheumatol Date: 2019-01-25 Impact factor: 10.995

7. Exposure to second-hand cigarette smoke exacerbates the progression of osteoarthritis in a surgical induced murine model.

Authors: Brandon J Rose; Jeffery A Weyand; Brady Liu; Jacob F Smith; Brian R Perez; J Christian Clark; Michael Goodman; Kelsey M Hirschi Budge; Dennis L Eggett; Juan A Arroyo; Paul R Reynolds; David L Kooyman
Journal: Histol Histopathol Date: 2021-02-12 Impact factor: 2.303