Literature DB >> 25489380

A novel triple medicine combination injection for the resolution of keloids and hypertrophic scars.

Nilesh N Goyal1, Michael H Gold2.   

Abstract

Keloids and hypertrophic scars remain one of the more difficult treatment concerns for clinicians. A variety of therapies have been used in the past with moderate success. On occasion, combination therapy has been used to treat these lesion, in an attempt to lessen the symptoms of pain and pruritus that often accompanies keloids and hypertrophic scars, as well as treating the actual lesions themselves. A novel triple combination injection process is introduced here in an attempt to further reduce the signs and symptoms of these lesions. The combination includes 5-fluoruracil, triamcinolone acetonide, and hyaluronidase. All three work in concert to treat keloids and hypertrophic scars, and this is the first work at looking at these medicines given together, at the same time, in a series of recalcitrant keloids and hypertrophic scars. The positive results warrant further investigation and hope for those with keloids and hypertrophic scars.

Entities:  

Year:  2014        PMID: 25489380      PMCID: PMC4255696     

Source DB:  PubMed          Journal:  J Clin Aesthet Dermatol        ISSN: 1941-2789


  7 in total

Review 1.  Keloids and hypertrophic scars.

Authors:  R S English; P D Shenefelt
Journal:  Dermatol Surg       Date:  1999-08       Impact factor: 3.398

Review 2.  International clinical recommendations on scar management.

Authors:  Thomas A Mustoe; Rodney D Cooter; Michael H Gold; F D Richard Hobbs; Albert-Adrien Ramelet; Peter G Shakespeare; Maurizio Stella; Luc Téot; Fiona M Wood; Ulrich E Ziegler
Journal:  Plast Reconstr Surg       Date:  2002-08       Impact factor: 4.730

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Authors:  F J Stucker; G Y Shaw
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1992-01

4.  New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars.

Authors:  Ali Asilian; Afshin Darougheh; Fazlolah Shariati
Journal:  Dermatol Surg       Date:  2006-07       Impact factor: 3.398

5.  Hyaluronidase in the management of pain due to post-laminectomy scar tissue.

Authors:  P A J Borg; H J Krijnen
Journal:  Pain       Date:  1994-08       Impact factor: 6.961

6.  Treatment of inflamed hypertrophic scars using intralesional 5-FU.

Authors:  R E Fitzpatrick
Journal:  Dermatol Surg       Date:  1999-03       Impact factor: 3.398

7.  Use of hyaluronidase cream to prevent peritoneal adhesions in laparoscopic ventral hernia repair by means of intraperitoneal mesh fixation using spiral tacks.

Authors:  Juan Martín-Cartes; Salvador Morales-Conde; Juan Suárez-Grau; Francisco López-Bernal; Manuel Bustos-Jiménez; Hisnard Cadet-Dussort; María Socas-Macías; José Alamo-Martínez; Juan D Tutosaus-Gómez; Slavador Morales-Mendez
Journal:  Surg Endosc       Date:  2008-03       Impact factor: 4.584

  7 in total
  1 in total

1.  Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds.

Authors:  Yssel Mendoza Marí; Maday Fernández Mayola; Ana Aguilera Barreto; Ariana García Ojalvo; Yilian Bermúdez Alvarez; Ana Janet Mir Benítez; Jorge Berlanga Acosta
Journal:  Plast Surg Int       Date:  2016-04-20
  1 in total

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