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Literature DB >> 2548922

Molecular evolution of the telomere-associated MAL loci of Saccharomyces.

M J Charron¹, E Read, S R Haut, C A Michels.

Abstract

The MAL gene family of Saccharomyces consists of five multigene complexes (MAL1, MAL2, MAL3, MAL4, and MAL6) each of which encodes maltose permease (GENE 1), maltase (GENE 2) and the trans-acting MAL-activator (GENE 3). Four of these loci have been mapped and each is located at or near the telomere of a different chromosome. We compare the physical structure of the MAL loci and their flanking sequences. The MAL loci were shown to be both structurally and functionally homologous throughout an approximately 9.0-kb region. The orientation of the MAL loci was determined to be: CENTROMERE . . . GENE 3-GENE 1-GENE 2 . . . TELOMERE. Telomere-adjacent sequences were found flanking GENE 2 of the MAL1, MAL3 and MAL6 loci. No common repeated elements were found on the centromere-proximal side of all the MAL1, loci. These results suggest that, during the evolution of this polygenic family, the MAL loci translocated to different chromosomes via a mechanism that involved the rearrangement(s) of chromosome termini.

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Year: 1989 PMID： 2548922 PMCID： PMC1203703

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

27 in total

1. Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal.

Authors: H J Cooke; W R Brown; G A Rappold
Journal: Nature Date: 1985 Oct 24-30 Impact factor: 49.962

2. Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae.

Authors: M J Charron; R A Dubin; C A Michels
Journal: Mol Cell Biol Date: 1986-11 Impact factor: 4.272

3. The constitutive, glucose-repression-insensitive mutation of the yeast MAL4 locus is an alteration of the MAL43 gene.

Authors: M J Charron; C A Michels
Journal: Genetics Date: 1987-05 Impact factor: 4.562

4. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

Authors: J M Ivy; A J Klar; J B Hicks
Journal: Mol Cell Biol Date: 1986-02 Impact factor: 4.272

5. Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast.

Authors: C Stachelek; J Stachelek; J Swan; D Botstein; W Konigsberg
Journal: Nucleic Acids Res Date: 1986-01-24 Impact factor: 16.971

6. Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres.

Authors: M Carlson; J L Celenza; F J Eng
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

7. Identification of a second trans-acting gene controlling maltose fermentation in Saccharomyces carlsbergensis.

Authors: R A Dubin; E L Perkins; R B Needleman; C A Michels
Journal: Mol Cell Biol Date: 1986-08 Impact factor: 4.272

8. Identification of the structural gene encoding maltase within the MAL6 locus of Saccharomyces carlsbergensis.

Authors: R A Dubin; R B Needleman; D Gossett; C A Michels
Journal: J Bacteriol Date: 1985-11 Impact factor: 3.490

9. Distribution of telomere-associated sequences on natural chromosomes in Saccharomyces cerevisiae.

Authors: V A Zakian; H M Blanton
Journal: Mol Cell Biol Date: 1988-05 Impact factor: 4.272

10. Constitutive expression of the maltose fermentative enzymes in Saccharomyces carlsbergensis is dependent upon the mutational activation of a nonessential homolog of MAL63.

Authors: R A Dubin; M J Charron; S R Haut; R B Needleman; C A Michels
Journal: Mol Cell Biol Date: 1988-03 Impact factor: 4.272

53 in total

1. Frequent meiotic recombination between the ends of truncated chromosome fragments of Saccharomyces cerevisiae.

Authors: T Arbel; R Shemesh; G Simchen
Journal: Genetics Date: 1999-12 Impact factor: 4.562

2. Phenotypic analysis of genes encoding yeast zinc cluster proteins.

Authors: B Akache; K Wu; B Turcotte
Journal: Nucleic Acids Res Date: 2001-05-15 Impact factor: 16.971

3. Characterization and functional analysis of the MAL and MPH Loci for maltose utilization in some ale and lager yeast strains.

Authors: Virve Vidgren; Laura Ruohonen; John Londesborough
Journal: Appl Environ Microbiol Date: 2005-12 Impact factor: 4.792

Molecular evolution of the telomere-associated MAL loci of Saccharomyces.

1. Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal.

2. Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae.

3. The constitutive, glucose-repression-insensitive mutation of the yeast MAL4 locus is an alteration of the MAL43 gene.

4. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

5. Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast.

6. Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres.

7. Identification of a second trans-acting gene controlling maltose fermentation in Saccharomyces carlsbergensis.

8. Identification of the structural gene encoding maltase within the MAL6 locus of Saccharomyces carlsbergensis.

9. Distribution of telomere-associated sequences on natural chromosomes in Saccharomyces cerevisiae.

10. Constitutive expression of the maltose fermentative enzymes in Saccharomyces carlsbergensis is dependent upon the mutational activation of a nonessential homolog of MAL63.

1. Frequent meiotic recombination between the ends of truncated chromosome fragments of Saccharomyces cerevisiae.

2. Phenotypic analysis of genes encoding yeast zinc cluster proteins.

3. Characterization and functional analysis of the MAL and MPH Loci for maltose utilization in some ale and lager yeast strains.

4. Rapid expansion and functional divergence of subtelomeric gene families in yeasts.

5. A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7.

6. Functional differentiation of tbf1 orthologues in fission and budding yeasts.

7. A complete set of marked telomeres in Saccharomyces cerevisiae for physical mapping and cloning.

8. A nomadic subtelomeric disease resistance gene cluster in common bean.

Review 9. Regulations of sugar transporters: insights from yeast.

10. Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose.