Literature DB >> 2548874

Mass changes of inositol(1,4,5)trisphosphate in trachealis muscle following agonist stimulation.

E R Chilvers1, R A Challiss, P J Barnes, S R Nahorski.   

Abstract

Agonist-stimulated changes in D-Ins(1,4,5)P3 has been examined in tracheal smooth muscle using a specific radioreceptor assay utilizing the binding of [3H] or [32P]Ins(1,4,5)P3 to a bovine adrenal cortex preparation. Carbachol produced a maximal increase in Ins(1,4,5)P3 concentration after 5 s (basal: 12.9 +/- 0.8; stimulated: 27 +/- 1.5 pmol/mg protein) with an EC50 of 6.7 +/- 0.8 microM. With longer stimulation periods Ins(1,4,5)P3 rapidly returned to basal values by 30 s. This is the first report of mass measurements of Ins(1,4,5)P3 in smooth muscle.

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Year:  1989        PMID： 2548874     DOI： 10.1016/0014-2999(89)90269-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  21 in total

1.  The effect of the PKC inhibitor GF109203X on the release of Ca2+ from internal stores and Ca2+ entry in DDT1 MF-2 cells.

Authors:  H Sipma; L van der Zee; J van den Akker; A den Hertog; A Nelemans
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

2.  Are there subtypes of the inositol 1,4,5-trisphosphate receptor?

Authors:  M A Varney; J Rivera; A Lopez Bernal; S P Watson
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

3.  Receptor-activated calcium influx in human airway smooth muscle cells.

Authors:  R K Murray; M I Kotlikoff
Journal:  J Physiol       Date:  1991-04       Impact factor: 5.182

4.  Maturational regulation of inositol 1,4,5-trisphosphate metabolism in rabbit airway smooth muscle.

Authors:  S M Rosenberg; G T Berry; J R Yandrasitz; M M Grunstein
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

5.  InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle.

Authors:  K Iizuka; A Yoshii; K Dobashi; T Horie; M Mori; T Nakazawa
Journal:  J Physiol       Date:  1998-09-15       Impact factor: 5.182

6.  Bradykinin B2 receptor-mediated phosphoinositide hydrolysis in bovine cultured tracheal smooth muscle cells.

Authors:  K A Marsh; S J Hill
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

7.  Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle.

Authors:  S Pyne; N J Pyne
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

8.  Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle.

Authors:  E R Chilvers; M A Giembycz; R A Challiss; B J Barnes; S R Nahorski
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

9.  Calcium release from separate receptor-specific intracellular stores induced by histamine and ATP in a hamster cell line.

Authors:  A Den Hertog; B Hoiting; A Molleman; J Van den Akker; M Duin; A Nelemans
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182

10.  Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle.

Authors:  R A Challiss; N Patel; J R Arch
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
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