Dan P Zandberg1,2, Sandy Liu3, Olga Goloubeva2, Robert Ord2,4, Scott E Strome5, Mohan Suntharalingam6, Rodney Taylor5, Robert E Morales7, Jeffrey S Wolf5, Ann Zimrin1,2, Joshua E Lubek2,4, Lisa M Schumaker2, Kevin J Cullen1,2. 1. Department of Medicine, Division of Medical Oncology, University of Maryland School of Medicine, Baltimore, Maryland. 2. University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland. 3. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland. 4. Department of Oral and Maxillofacial Surgery, University of Maryland School of Medicine, Baltimore, Maryland. 5. Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland. 6. Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland. 7. Department of Radiology, University of Maryland School of Medicine, Baltimore, Maryland.
Abstract
BACKGROUND: Racial outcome disparities have been observed in head and neck squamous cell carcinoma (HNSCC) with diminished survival for black patients compared with white patients. METHODS: We retrospectively analyzed 1318 patients with primary HNSCC treated at the University of Maryland Greenebaum Cancer Center (UMGCC) from 2000 to 2010. RESULTS: Of all the patients, 65.9% were white, 30.7% were black, and 3.3% were of other races. Black patients were less likely to present with oral cavity cancer, and more likely to present with laryngeal or hypopharyngeal cancers. White patients were more likely to have early stage disease, especially in the oral cavity. Black race was independently associated with worse overall survival (OS) in the entire cohort. Black patients had a significantly worse OS among oral cavity and oropharyngeal cancers, with the largest disparity in oropharyngeal cancer. However, in multivariate analysis, race was only still significant in oropharyngeal cancer. CONCLUSION: We observed differences by race in distribution of disease site, stage, and OS. Survival disparity in the entire cohort was driven mostly by differences among oropharyngeal cancer.
BACKGROUND: Racial outcome disparities have been observed in head and neck squamous cell carcinoma (HNSCC) with diminished survival for black patients compared with white patients. METHODS: We retrospectively analyzed 1318 patients with primary HNSCC treated at the University of Maryland Greenebaum Cancer Center (UMGCC) from 2000 to 2010. RESULTS: Of all the patients, 65.9% were white, 30.7% were black, and 3.3% were of other races. Black patients were less likely to present with oral cavity cancer, and more likely to present with laryngeal or hypopharyngeal cancers. White patients were more likely to have early stage disease, especially in the oral cavity. Black race was independently associated with worse overall survival (OS) in the entire cohort. Black patients had a significantly worse OS among oral cavity and oropharyngeal cancers, with the largest disparity in oropharyngeal cancer. However, in multivariate analysis, race was only still significant in oropharyngeal cancer. CONCLUSION: We observed differences by race in distribution of disease site, stage, and OS. Survival disparity in the entire cohort was driven mostly by differences among oropharyngeal cancer.
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