Xuan Gao1, Chunyu Chu2, Yingci Li1, Peiou Lu1, Wenzhi Wang1, Wanyu Liu2, Lijuan Yu3. 1. Center of PET/CT, The Third Affiliated Hospital of Harbin Medical University, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. 2. HIT-INSA Sino French Research Centre for Biomedical Imaging, Harbin Institute of Technology, Harbin, China. 3. Center of PET/CT, The Third Affiliated Hospital of Harbin Medical University, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. Electronic address: yulijuan2003@126.com.
Abstract
OBJECTIVES: In clinical practice, image analysis is dependent on simply visual perception and the diagnostic efficacy of this analysis pattern is limited for mediastinal lymph nodes in patients with lung cancer. In order to improve diagnostic efficacy, we developed a new computer-based algorithm and tested its diagnostic efficacy. METHODS: 132 consecutive patients with lung cancer underwent (18)F-FDG PET/CT examination before treatment. After all data were imported into the database of an on-line medical image analysis platform, the diagnostic efficacy of visual analysis was first evaluated without knowing pathological results, and the maximum short diameter and maximum standardized uptake value (SUVmax) were measured. Then lymph nodes were segmented manually. Three classifiers based on support vector machine (SVM) were constructed from CT, PET, and combined PET-CT images, respectively. The diagnostic efficacy of SVM classifiers was obtained and evaluated. RESULTS: According to ROC curves, the areas under curves for maximum short diameter and SUVmax were 0.684 and 0.652, respectively. The areas under the ROC curve for SVM1, SVM2, and SVM3 were 0.689, 0.579, and 0.685, respectively. CONCLUSION: The algorithm based on SVM was potential in the diagnosis of mediastinal lymph nodes.
OBJECTIVES: In clinical practice, image analysis is dependent on simply visual perception and the diagnostic efficacy of this analysis pattern is limited for mediastinal lymph nodes in patients with lung cancer. In order to improve diagnostic efficacy, we developed a new computer-based algorithm and tested its diagnostic efficacy. METHODS: 132 consecutive patients with lung cancer underwent (18)F-FDG PET/CT examination before treatment. After all data were imported into the database of an on-line medical image analysis platform, the diagnostic efficacy of visual analysis was first evaluated without knowing pathological results, and the maximum short diameter and maximum standardized uptake value (SUVmax) were measured. Then lymph nodes were segmented manually. Three classifiers based on support vector machine (SVM) were constructed from CT, PET, and combined PET-CT images, respectively. The diagnostic efficacy of SVM classifiers was obtained and evaluated. RESULTS: According to ROC curves, the areas under curves for maximum short diameter and SUVmax were 0.684 and 0.652, respectively. The areas under the ROC curve for SVM1, SVM2, and SVM3 were 0.689, 0.579, and 0.685, respectively. CONCLUSION: The algorithm based on SVM was potential in the diagnosis of mediastinal lymph nodes.
Authors: Ke Nie; Hania Al-Hallaq; X Allen Li; Stanley H Benedict; Jason W Sohn; Jean M Moran; Yong Fan; Mi Huang; Michael V Knopp; Jeff M Michalski; James Monroe; Ceferino Obcemea; Christina I Tsien; Timothy Solberg; Jackie Wu; Ping Xia; Ying Xiao; Issam El Naqa Journal: Int J Radiat Oncol Biol Phys Date: 2019-01-31 Impact factor: 7.038
Authors: Philippe Lambin; Ralph T H Leijenaar; Timo M Deist; Jurgen Peerlings; Evelyn E C de Jong; Janita van Timmeren; Sebastian Sanduleanu; Ruben T H M Larue; Aniek J G Even; Arthur Jochems; Yvonka van Wijk; Henry Woodruff; Johan van Soest; Tim Lustberg; Erik Roelofs; Wouter van Elmpt; Andre Dekker; Felix M Mottaghy; Joachim E Wildberger; Sean Walsh Journal: Nat Rev Clin Oncol Date: 2017-10-04 Impact factor: 66.675